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Review

Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity

by
Karolina Kula
1,*,
Roman Nagatsky
1,
Mikołaj Sadowski
1,
Yevheniia Siumka
2 and
Oleg M. Demchuk
3,*
1
Department of Organic Chemistry and Technology, Cracow University of Technology, Warszawska 24, 31-155 Krakow, Poland
2
Institute for Advanced Training of Pharmacy Specialists, National University of Pharmacy, 17 Zahysnynykiv Ukrainy sq., 61001 Kharkiv, Ukraine
3
Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynow 1J, 20-708 Lublin, Poland
*
Authors to whom correspondence should be addressed.
Molecules 2023, 28(13), 5229; https://doi.org/10.3390/molecules28135229
Submission received: 14 May 2023 / Revised: 12 June 2023 / Accepted: 28 June 2023 / Published: 5 July 2023
(This article belongs to the Special Issue Feature Papers in Organic Chemistry (Volume II))
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Abstract

Quinone methides are a class of biologically active compounds that can be used in medicine as antibacterial, antifungal, antiviral, antioxidant, and anti-inflammatory agents. In addition, quinone methides have the potential to be used as pesticides, dyes, and additives for rubber and plastics. In this paper, we discuss a subclass of quinone methides: methylenequinone oximes. Although the first representatives of the subgroup were synthesized in the distant past, they still need to be additionally studied, while their chemistry, biological properties, and perspective of practical applications require to be comprehensively summarised. Based on the analysis of the literature, it can be concluded that methylenequinone oximes exhibit a diversified profile of properties and outstanding potential as new drug candidates and reagents in organic synthesis, both of electrophilic and nucleophilic nature, worthy of wide-ranging further research.
Keywords: quinonemethide; arylcyanomethylenequinone oximes; quinone; chemical transformation; biological activity quinonemethide; arylcyanomethylenequinone oximes; quinone; chemical transformation; biological activity

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MDPI and ACS Style

Kula, K.; Nagatsky, R.; Sadowski, M.; Siumka, Y.; Demchuk, O.M. Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity. Molecules 2023, 28, 5229. https://doi.org/10.3390/molecules28135229

AMA Style

Kula K, Nagatsky R, Sadowski M, Siumka Y, Demchuk OM. Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity. Molecules. 2023; 28(13):5229. https://doi.org/10.3390/molecules28135229

Chicago/Turabian Style

Kula, Karolina, Roman Nagatsky, Mikołaj Sadowski, Yevheniia Siumka, and Oleg M. Demchuk. 2023. "Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity" Molecules 28, no. 13: 5229. https://doi.org/10.3390/molecules28135229

APA Style

Kula, K., Nagatsky, R., Sadowski, M., Siumka, Y., & Demchuk, O. M. (2023). Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity. Molecules, 28(13), 5229. https://doi.org/10.3390/molecules28135229

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