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Review

A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship

1
Department of Pharmacy, Jashore University of Science and Technology, Jashore 7408, Bangladesh
2
School of Optometry and Vision Science, UNSW Medicine, University of New South Wales (UNSW), Sydney, NSW 2052, Australia
3
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1207, Bangladesh
4
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka 1207, Bangladesh
5
Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan
*
Authors to whom correspondence should be addressed.
Academic Editors: Oksana Sytar and Iryna Smetanska
Molecules 2022, 27(9), 3036; https://doi.org/10.3390/molecules27093036
Received: 16 April 2022 / Revised: 4 May 2022 / Accepted: 5 May 2022 / Published: 9 May 2022
(This article belongs to the Special Issue Bioactive Compounds from Natural Sources II)
Cancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current conventional therapies. Researchers around the world are drawing their attention towards compounds of natural origin. For decades, human beings have been using the flora of the world as a source of cancer chemotherapeutic agents. Currently, clinically approved anticancer compounds are vincristine, vinblastine, taxanes, and podophyllotoxin, all of which come from natural sources. With the triumph of these compounds that have been developed into staple drug products for most cancer therapies, new technologies are now appearing to search for novel biomolecules with anticancer activities. Ellipticine, camptothecin, combretastatin, curcumin, homoharringtonine and others are plant derived bioactive phytocompounds with potential anticancer properties. Researchers have improved the field further through the use of advanced analytical chemistry and computational tools of analysis. The investigation of new strategies for administration such as nanotechnology may enable the development of the phytocompounds as drug products. These technologies have enhanced the anticancer potential of plant-derived drugs with the aim of site-directed drug delivery, enhanced bioavailability, and reduced toxicity. This review discusses mechanistic insights into anticancer compounds of natural origins and their structural activity relationships that make them targets for anticancer treatments. View Full-Text
Keywords: neoplastic disease; proliferation; anticancer bioactive phytocompounds; structure activity relationship (SAR); cytotoxic agents neoplastic disease; proliferation; anticancer bioactive phytocompounds; structure activity relationship (SAR); cytotoxic agents
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MDPI and ACS Style

Mazumder, K.; Aktar, A.; Roy, P.; Biswas, B.; Hossain, M.E.; Sarkar, K.K.; Bachar, S.C.; Ahmed, F.; Monjur-Al-Hossain, A.S.M.; Fukase, K. A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship. Molecules 2022, 27, 3036. https://doi.org/10.3390/molecules27093036

AMA Style

Mazumder K, Aktar A, Roy P, Biswas B, Hossain ME, Sarkar KK, Bachar SC, Ahmed F, Monjur-Al-Hossain ASM, Fukase K. A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship. Molecules. 2022; 27(9):3036. https://doi.org/10.3390/molecules27093036

Chicago/Turabian Style

Mazumder, Kishor, Asma Aktar, Priyanka Roy, Biswajit Biswas, Md. Emran Hossain, Kishore Kumar Sarkar, Sitesh Chandra Bachar, Firoj Ahmed, A. S. M. Monjur-Al-Hossain, and Koichi Fukase. 2022. "A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship" Molecules 27, no. 9: 3036. https://doi.org/10.3390/molecules27093036

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