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Review

Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer

1
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia
2
Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia
3
Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editors: Luciana Mosca, Antonio Francioso and Roberto Mattioli
Molecules 2022, 27(9), 2665; https://doi.org/10.3390/molecules27092665
Received: 3 March 2022 / Revised: 18 April 2022 / Accepted: 19 April 2022 / Published: 21 April 2022
Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy modes employed, including chemotherapy and radiotherapy, have been reported to be significant in cancer management, but the side effects associated with these treatment strategies are still a health problem. Therefore, alternative anticancer drugs based on medicinal plants or their active compounds have been generating attention because of their less serious side effects. Medicinal plants are an excellent source of phytochemicals that have been recognized to have health-prompting effects through modulating cell signaling pathways. Resveratrol is a well-known polyphenolic molecule with antioxidant, anti-inflammatory, and health-prompting effects among which its anticancer role has been best defined. Additionally, this polyphenol has confirmed its role in cancer management because it activates tumor suppressor genes, suppresses cell proliferation, induces apoptosis, inhibits angiogenesis, and modulates several other cell signaling molecules. The anticancer potential of resveratrol is recognized in numerous in vivo and in vitro studies. Previous experimental data suggested that resveratrol may be valuable in cancer management or improve the efficacy of drugs when given with anticancer drugs. This review emphasizes the potential role of resveratrol as an anticancer drug by modulating numerous cells signaling pathways in different types of cancer. View Full-Text
Keywords: resveratrol; cell signaling pathways; cancers; clinical trials; synergistic effect resveratrol; cell signaling pathways; cancers; clinical trials; synergistic effect
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MDPI and ACS Style

Almatroodi, S.A.; A. Alsahli, M.; S. M. Aljohani, A.; Alhumaydhi, F.A.; Babiker, A.Y.; Khan, A.A.; Rahmani, A.H. Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer. Molecules 2022, 27, 2665. https://doi.org/10.3390/molecules27092665

AMA Style

Almatroodi SA, A. Alsahli M, S. M. Aljohani A, Alhumaydhi FA, Babiker AY, Khan AA, Rahmani AH. Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer. Molecules. 2022; 27(9):2665. https://doi.org/10.3390/molecules27092665

Chicago/Turabian Style

Almatroodi, Saleh A., Mohammed A. Alsahli, Abdullah S. M. Aljohani, Fahad A. Alhumaydhi, Ali Yousif Babiker, Amjad Ali Khan, and Arshad Husain Rahmani. 2022. "Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer" Molecules 27, no. 9: 2665. https://doi.org/10.3390/molecules27092665

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