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Review

Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

by
Ramón Rodrigo
1,*,
Catalina Retamal
1,
Denisse Schupper
1,
Diego Vergara-Hernández
1,
Sarmistha Saha
2,
Elisabetta Profumo
3,
Brigitta Buttari
3 and
Luciano Saso
4
1
Molecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago P.O. Box 70111, Chile
2
Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382055, Gujarat, India
3
Department of Cardiovascular, Endocrine-Metabolic Diseases, and Aging, Italian National Institute of Health, 00161 Rome, Italy
4
Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(8), 2564; https://doi.org/10.3390/molecules27082564
Submission received: 4 March 2022 / Revised: 6 April 2022 / Accepted: 12 April 2022 / Published: 15 April 2022
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Abstract

Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. Although this damage could account for up to 50% of the final infarct size, there has been no available pharmacological treatment until now. Oxidative stress contributes to the underlying production mechanism, exerting the most marked injury during the early onset of reperfusion. So far, antioxidants have been shown to protect the AMI patients undergoing PCI to mitigate these detrimental effects; however, no clinical trials to date have shown any significant infarct size reduction. Therefore, it is worthwhile to consider multitarget antioxidant therapies targeting multifactorial AMI. Indeed, this clinical setting involves injurious effects derived from oxygen deprivation, intracellular pH changes and increased concentration of cytosolic Ca2+ and reactive oxygen species, among others. Thus, we will review a brief overview of the pathological cascades involved in ischemia-reperfusion injury and the potential therapeutic effects based on preclinical studies involving a combination of antioxidants, with particular reference to resveratrol and quercetin, which could contribute to cardioprotection against ischemia-reperfusion injury in myocardial tissue. We will also highlight the upcoming perspectives of these antioxidants for designing future studies.
Keywords: oxidative stress; reperfusion injury; antioxidants; resveratrol; quercetin; cardioprotection oxidative stress; reperfusion injury; antioxidants; resveratrol; quercetin; cardioprotection

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MDPI and ACS Style

Rodrigo, R.; Retamal, C.; Schupper, D.; Vergara-Hernández, D.; Saha, S.; Profumo, E.; Buttari, B.; Saso, L. Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin. Molecules 2022, 27, 2564. https://doi.org/10.3390/molecules27082564

AMA Style

Rodrigo R, Retamal C, Schupper D, Vergara-Hernández D, Saha S, Profumo E, Buttari B, Saso L. Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin. Molecules. 2022; 27(8):2564. https://doi.org/10.3390/molecules27082564

Chicago/Turabian Style

Rodrigo, Ramón, Catalina Retamal, Denisse Schupper, Diego Vergara-Hernández, Sarmistha Saha, Elisabetta Profumo, Brigitta Buttari, and Luciano Saso. 2022. "Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin" Molecules 27, no. 8: 2564. https://doi.org/10.3390/molecules27082564

APA Style

Rodrigo, R., Retamal, C., Schupper, D., Vergara-Hernández, D., Saha, S., Profumo, E., Buttari, B., & Saso, L. (2022). Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin. Molecules, 27(8), 2564. https://doi.org/10.3390/molecules27082564

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