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Electroporation and Electrochemotherapy in Gynecological and Breast Cancer Treatment

Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland
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Academic Editors: David Barker and Iola F. Duarte Ciceco
Molecules 2022, 27(8), 2476; https://doi.org/10.3390/molecules27082476
Received: 5 February 2022 / Revised: 14 March 2022 / Accepted: 10 April 2022 / Published: 12 April 2022
(This article belongs to the Special Issue Electroporation - Drug Delivery and Anticancer Approach)
Gynecological carcinomas affect an increasing number of women and are associated with poor prognosis. The gold standard treatment plan is mainly based on surgical resection and subsequent chemotherapy with cisplatin, 5-fluorouracil, anthracyclines, or taxanes. Unfortunately, this treatment is becoming less effective and is associated with many side effects that negatively affect patients’ physical and mental well-being. Electroporation based on tumor exposure to electric pulses enables reduction in cytotoxic drugs dose while increasing their effectiveness. EP-based treatment methods have received more and more interest in recent years and are the subject of a large number of scientific studies. Some of them show promising therapeutic potential without using any cytotoxic drugs or molecules already present in the human body (e.g., calcium electroporation). This literature review aims to present the fundamental mechanisms responsible for the course of EP-based therapies and the current state of knowledge in the field of their application in the treatment of gynecological neoplasms. View Full-Text
Keywords: gynecological cancer; breast cancer; electrochemotherapy; electroporation; calcium electroporation gynecological cancer; breast cancer; electrochemotherapy; electroporation; calcium electroporation
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MDPI and ACS Style

Łapińska, Z.; Szwedowicz, U.; Choromańska, A.; Saczko, J. Electroporation and Electrochemotherapy in Gynecological and Breast Cancer Treatment. Molecules 2022, 27, 2476. https://doi.org/10.3390/molecules27082476

AMA Style

Łapińska Z, Szwedowicz U, Choromańska A, Saczko J. Electroporation and Electrochemotherapy in Gynecological and Breast Cancer Treatment. Molecules. 2022; 27(8):2476. https://doi.org/10.3390/molecules27082476

Chicago/Turabian Style

Łapińska, Zofia, Urszula Szwedowicz, Anna Choromańska, and Jolanta Saczko. 2022. "Electroporation and Electrochemotherapy in Gynecological and Breast Cancer Treatment" Molecules 27, no. 8: 2476. https://doi.org/10.3390/molecules27082476

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