Next Article in Journal
Benefits of the Mediterranean Diet–Wine Association: The Role of Ingredients
Previous Article in Journal
The Utilization of Algae and Seaweed Biomass for Bioremediation of Heavy Metal-Contaminated Wastewater
Previous Article in Special Issue
GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
 
 
Article

Selective Consumption of Fish Oil at End of the Day Increases the Physiological Fatty Acid Compositions of Eicosapentaenoic Acid and Docosahexaenoic Acid in Mice

1
Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, Japan
2
Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Shaikh Mizanoor Rahman and Masao Yamasaki
Molecules 2022, 27(4), 1271; https://doi.org/10.3390/molecules27041271
Received: 19 December 2021 / Revised: 8 February 2022 / Accepted: 8 February 2022 / Published: 14 February 2022
(This article belongs to the Special Issue Dietary Bioactive Compounds and Their Health Implications)
Diets with high daily fat consumption are associated with excess weight. However, the effects of fat type and consumption timing on excess weight remain unclear. We investigated the selection of a 30% (w/w) fat diet of soybean oil (SOY), lard (LARD), and fish oil (FISH) on the metabolic parameters of mice. Male C57BL/6 mice were divided into the double SOY-box (w-SOY), SOY-box/LARD-box (SOY-vs-LARD), or SOY-box/FISH-box (SOY-vs-FISH) groups and allowed to selectively consume for 8 weeks. The total energy intake was similar for all groups, but the mice selectively chose to consume LARD over SOY and SOY over FISH. Body weight in the SOY-vs-LARD group was significantly higher than that in the w-SOY and SOY-vs-FISH groups. Additionally, minimal but selective consumption of an omega-3 fatty-acid-rich FISH diet at the end of the active period increased the physiological fatty acid compositions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the SOY-vs-FISH group; their metabolic parameters were also lower than the SOY-vs-LARD group. In conclusion, selectively consuming small amounts of fish oil at the end of the day may prevent excess weight compared with LARD consumption. View Full-Text
Keywords: high-fat diet; mice; overweight; omega-3/omega-6 ratio; selectivity high-fat diet; mice; overweight; omega-3/omega-6 ratio; selectivity
Show Figures

Graphical abstract

MDPI and ACS Style

Matsuzaka, H.; Matsuyama, H.; Tanaka, W.; Tajiri, H.; Sakakibara, H. Selective Consumption of Fish Oil at End of the Day Increases the Physiological Fatty Acid Compositions of Eicosapentaenoic Acid and Docosahexaenoic Acid in Mice. Molecules 2022, 27, 1271. https://doi.org/10.3390/molecules27041271

AMA Style

Matsuzaka H, Matsuyama H, Tanaka W, Tajiri H, Sakakibara H. Selective Consumption of Fish Oil at End of the Day Increases the Physiological Fatty Acid Compositions of Eicosapentaenoic Acid and Docosahexaenoic Acid in Mice. Molecules. 2022; 27(4):1271. https://doi.org/10.3390/molecules27041271

Chicago/Turabian Style

Matsuzaka, Hiroki, Hiroki Matsuyama, Wataru Tanaka, Hayato Tajiri, and Hiroyuki Sakakibara. 2022. "Selective Consumption of Fish Oil at End of the Day Increases the Physiological Fatty Acid Compositions of Eicosapentaenoic Acid and Docosahexaenoic Acid in Mice" Molecules 27, no. 4: 1271. https://doi.org/10.3390/molecules27041271

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop