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Article

Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation

by
Mara Heckmann
1,2,
Nadiia Sadova
1,
Ivana Drotarova
1,2,
Stefanie Atzmüller
1,2,
Bettina Schwarzinger
1,2,
Roberto Mauricio Carvalho Guedes
3,
Paula Angelica Correia
3,
Stefan Hirtenlehner
4,
Christine Potthast
4,
Gerald Klanert
2 and
Julian Weghuber
1,2,*
1
Center of Excellence Food Technology and Nutrition, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, 4600 Wels, Austria
2
FFoQSI GmbH–Austrian Competence Centre for Feed and Food Quality, Safety and Innovation, Technopark 1D, 3430 Tulln, Austria
3
Department of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte 130161-970, Brazil
4
Agromed GmbH, Bad Haller Str. 23, 4550 Kremsmünster, Austria
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(19), 6327; https://doi.org/10.3390/molecules27196327
Submission received: 25 August 2022 / Revised: 21 September 2022 / Accepted: 22 September 2022 / Published: 26 September 2022
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Lignans are known to exhibit a broad spectrum of biological activities, indicating their potential as constituents of feed supplements. This study investigated two extracts derived from the feed supplements ‘ROI’ and ‘Protect’—which contain the wood lignans magnolol and honokiol (‘ROI’), or soluble tannins additional to the aforementioned lignans (‘Protect’)—and their impact on selected parameters of intestinal functionality. The antioxidant and anti-inflammatory properties of the extracts were determined by measuring their effects on reactive oxygen species (ROS) and pro-inflammatory cytokine production in vitro. The impact on intestinal barrier integrity was evaluated in Caco-2 cells and Drosophila melanogaster by examining leaky gut formation. Furthermore, a feeding trial using infected piglets was conducted to study the impact on the levels of superoxide dismutase, glutathione and lipid peroxidation. The Protect extract lowered ROS production in Caco-2 cells and reversed the stress-induced weakening of barrier integrity. The ROI extract inhibited the expression or secretion of interleukin-8 (IL-8), interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα). Moreover, the ROI extract decreased leaky gut formation and mortality rates in Drosophila melanogaster. Dietary supplementation with Protect improved the antioxidant status and barrier integrity of the intestines of infected piglets. In conclusion, wood lignan-enriched feed supplements are valuable tools that support intestinal health by exerting antioxidant, anti-inflammatory and barrier-strengthening effects.
Keywords: feed supplements; intestinal barrier; wood lignans; barrier integrity; intestinal permeability feed supplements; intestinal barrier; wood lignans; barrier integrity; intestinal permeability

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MDPI and ACS Style

Heckmann, M.; Sadova, N.; Drotarova, I.; Atzmüller, S.; Schwarzinger, B.; Guedes, R.M.C.; Correia, P.A.; Hirtenlehner, S.; Potthast, C.; Klanert, G.; et al. Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation. Molecules 2022, 27, 6327. https://doi.org/10.3390/molecules27196327

AMA Style

Heckmann M, Sadova N, Drotarova I, Atzmüller S, Schwarzinger B, Guedes RMC, Correia PA, Hirtenlehner S, Potthast C, Klanert G, et al. Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation. Molecules. 2022; 27(19):6327. https://doi.org/10.3390/molecules27196327

Chicago/Turabian Style

Heckmann, Mara, Nadiia Sadova, Ivana Drotarova, Stefanie Atzmüller, Bettina Schwarzinger, Roberto Mauricio Carvalho Guedes, Paula Angelica Correia, Stefan Hirtenlehner, Christine Potthast, Gerald Klanert, and et al. 2022. "Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation" Molecules 27, no. 19: 6327. https://doi.org/10.3390/molecules27196327

APA Style

Heckmann, M., Sadova, N., Drotarova, I., Atzmüller, S., Schwarzinger, B., Guedes, R. M. C., Correia, P. A., Hirtenlehner, S., Potthast, C., Klanert, G., & Weghuber, J. (2022). Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation. Molecules, 27(19), 6327. https://doi.org/10.3390/molecules27196327

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