Biological Effects of EGCG@MOF Zn(BTC)4 System Improves Wound Healing in Diabetes

Li, Song; Yan, Jing; Zhu, Qiangqiang; Liu, Xinxiang; Li, Senlin; Wang, Shenhou; Wang, Xuanjun; Sheng, Jun

doi:10.3390/molecules27175427

Open AccessArticle

Biological Effects of EGCG@MOF Zn(BTC)₄ System Improves Wound Healing in Diabetes

by

Song Li

^1,*,†,

Jing Yan

^2,3,†,

Qiangqiang Zhu

²,

Xinxiang Liu

²,

Senlin Li

¹,

Shenhou Wang

¹,

Xuanjun Wang

^1,2,* and

Jun Sheng

^2,*

¹

College of Science, Yunnan Agricultural University, Kunming 650201, China

²

Key Laborotory of Puer Tea Sciencs, Ministry of Education(YNAU), Yunnan Agricultural University, Kunming 650201, China

³

Agro-Products Processing Research Institute, Yunnan Academy of Agricultural Sciences, Kunming 650201, China

^*

Authors to whom correspondence should be addressed.

^†

These authors have contributed equally to this work.

Molecules 2022, 27(17), 5427; https://doi.org/10.3390/molecules27175427

Submission received: 12 July 2022 / Revised: 10 August 2022 / Accepted: 12 August 2022 / Published: 25 August 2022

(This article belongs to the Special Issue Metal Organic Frameworks: Synthesis and Application II)

Download

Browse Figures

Review Reports Versions Notes

Abstract

Tea contains high levels of the compound epigallocatechin gallate (EGCG). It is considered an important functional component in tea and has anti-cancer, antioxidant, and anti-inflammatory effects. The eight phenolic hydroxyl groups in EGCG’s chemical structure are the basis for EGCG’s multiple biological effects. At the same time, it also leads to poor chemical stability, rendering EGCG prone to oxidation and isomerization reactions that change its original structure and biological activity. Learning how to maintain the activity of EGCG has become an important goal in understanding the biological activity of EGCG and the research and development of tea-related products. Metal–organic frameworks (MOFs) are porous materials with a three-dimensional network structure that are composed of inorganic metals or metal clusters together with organic complexes. MOFs exploit the porous nature of the material itself. When a drug is an appropriate size, it can be wrapped into the pores by physical or chemical methods; this allows the drug to be released slowly, and MOFs can also reduce drug toxicity. In this study, we used MOF Zn(BTC)₄ materials to load EGCG and investigated the sustained release effect of EGCG@MOF Zn(BTC)₄ and the biological effects on wound healing in a diabetic mouse model.

Keywords: EGCG; MOF; wound healing; diabetes

Graphical Abstract

Share and Cite

MDPI and ACS Style

Li, S.; Yan, J.; Zhu, Q.; Liu, X.; Li, S.; Wang, S.; Wang, X.; Sheng, J. Biological Effects of EGCG@MOF Zn(BTC)₄ System Improves Wound Healing in Diabetes. Molecules 2022, 27, 5427. https://doi.org/10.3390/molecules27175427

AMA Style

Li S, Yan J, Zhu Q, Liu X, Li S, Wang S, Wang X, Sheng J. Biological Effects of EGCG@MOF Zn(BTC)₄ System Improves Wound Healing in Diabetes. Molecules. 2022; 27(17):5427. https://doi.org/10.3390/molecules27175427

Chicago/Turabian Style

Li, Song, Jing Yan, Qiangqiang Zhu, Xinxiang Liu, Senlin Li, Shenhou Wang, Xuanjun Wang, and Jun Sheng. 2022. "Biological Effects of EGCG@MOF Zn(BTC)₄ System Improves Wound Healing in Diabetes" Molecules 27, no. 17: 5427. https://doi.org/10.3390/molecules27175427

APA Style

Li, S., Yan, J., Zhu, Q., Liu, X., Li, S., Wang, S., Wang, X., & Sheng, J. (2022). Biological Effects of EGCG@MOF Zn(BTC)₄ System Improves Wound Healing in Diabetes. Molecules, 27(17), 5427. https://doi.org/10.3390/molecules27175427

Article Menu

Biological Effects of EGCG@MOF Zn(BTC)₄ System Improves Wound Healing in Diabetes

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI