Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications
Abstract
:1. Introduction
2. Results and Discussion
2.1. Preparation and Characterization of Yeast Particles Hyper-Loaded with Terpenes
Terpene | Log P * | Solubility in Water * (mg/mL) |
---|---|---|
Geraniol | 3.56 | 0.686 |
Eugenol | 2.27 | 1.44 |
Thymol | 3.3 | 0.9 |
2.2. Terpene Release from Hyper-Loaded YP-GET
2.3. Biological Activity of Hyper-Loaded YP GET
2.4. Optimization of Hyper-Loaded YP-GET Formulations as Dry Granules or Aqueous Suspension Concentrates
3. Materials and Methods
4. Conclusions
5. Patents
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Sample | Minimum Inhibitory Concentration (MIC 75%) | ||
---|---|---|---|
E. coli | S. aureus | C. albicans | |
Empty YPs | Not active | Not active | Not active |
YP-GET 1.1:1 | 0.156 ± 0.05 | 0.313 ± 0 | 0.156 ± 0.026 |
YP-GET 2:1 | 0.156 ± 0.06 | 0.313 ± 0 | 0.156 ± 0.026 |
YP-GET 3:1 | 0.156 ± 0.05 | 0.313 ± 0 | 0.156 ± 0.026 |
YP-GET 4:1 | 0.156 ± 0.03 | 0.313 ± 0 | 0.156 ± 0.039 |
YP-GET 5:1 | 0.156 ± 0.05 | 0.313 ± 0 | 0.156 ± 0.030 |
Unencapsulated GET | 0.625 ± 0 **** | 1.250 ± 0.318 * | 0.625 ± 0 *** |
Ampicillin | 0.008 **** | <0.00025 **** | - |
Fluconazole | - | - | <2 **** |
GET:YP Ratio | Materials to Produce 100 g YP-GET | Final Composition | |||
---|---|---|---|---|---|
g YP | mL (g) Water | g GET | %YP | %GET | |
1.1:1 | 15 | 68.5 | 16.5 | 15 | 16.5 |
2:1 | 15 | 55 | 30 | 15 | 30 |
3:1 | 15 | 40 | 45 | 15 | 45 |
4:1 | 15 | 25 | 60 | 15 | 60 |
5:1 | 15 | 10 | 75 | 15 | 75 |
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Soto, E.R.; Rus, F.; Ostroff, G.R. Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications. Molecules 2022, 27, 3580. https://doi.org/10.3390/molecules27113580
Soto ER, Rus F, Ostroff GR. Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications. Molecules. 2022; 27(11):3580. https://doi.org/10.3390/molecules27113580
Chicago/Turabian StyleSoto, Ernesto R., Florentina Rus, and Gary R. Ostroff. 2022. "Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications" Molecules 27, no. 11: 3580. https://doi.org/10.3390/molecules27113580