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Open AccessArticle

Effect of Fish Bone Bioactive Peptides on Oxidative, Inflammatory and Pigmentation Processes Triggered by UVB Irradiation in Skin Cells

1
National Institute of R&D for Biological Sciences, 296, Splaiul Independentei, 060031 Bucharest, Romania
2
Faculty of Biology, University of Bucharest, 91-95, Splaiul Independentei, 050095 Bucharest, Romania
3
Laboratoarele Medica SRL, 11, Frasinului Street, 075100 Otopeni, Romania
4
National Institute for R&D in Chemistry and Petrochemistry—Icechim, 202, Splaiul Independentei, 060021 Bucharest, Romania
*
Author to whom correspondence should be addressed.
These authors have equally contributed to this work.
Academic Editor: Dana Maria Copolovici
Molecules 2021, 26(9), 2691; https://doi.org/10.3390/molecules26092691
Received: 15 April 2021 / Revised: 30 April 2021 / Accepted: 3 May 2021 / Published: 4 May 2021
In the present study, we evaluated for the first time the photoprotective effect of fish bone bioactive peptides (FBBP) preparation isolated from silver carp (Hypophthalmichthys molitrix) discarded tissue using in vitro experimental models of skin cells exposed to ultraviolet B (UVB) irradiation and stressing agents. FBBP preparation was obtained by papain treatment of minced bones and centrifugal ultrafiltration, and the molecular weight (MW) distribution was characterized by size exclusion and reversed-phase high performance liquid chromatography (RP-HPLC). In vitro assessment of the effect of FBBP pretreatment in UVB-irradiated L929 fibroblasts and HaCaT keratinocytes revealed their cytoprotective activity. Their capacity to efficiently reduce reactive oxygen species (ROS) production and lipid peroxidation varied in a dose-dependent manner, and it was greater in fibroblasts. A decrease of proinflammatory cytokines secretion, in particular of tumor necrosis factor alpha (TNF-α), was found after FBBP pretreatment of THP-1-derived inflamed macrophages. Melanin production and tyrosinase activity investigated in UVB-irradiated Mel-Juso cells were lowered in direct relation to FBBP concentrations. FBBP fractions with high radical scavenging activity were separated by ion exchange chromatography, and two collagenic sequences were identified. All these results offer new scientific data on aquaculture fish bone-derived peptides confirming their ability to control the antioxidant, anti-inflammatory and pigmentation processes developed during UV irradiation of skin cells and recommend their use as valuable natural ingredients of photoprotective cosmeceutical products. View Full-Text
Keywords: collagen peptides; free radicals scavenging; antioxidant activity; biological activity; proinflammatory cytokines; melanogenesis; lipid peroxidation; photoaging; sunscreen collagen peptides; free radicals scavenging; antioxidant activity; biological activity; proinflammatory cytokines; melanogenesis; lipid peroxidation; photoaging; sunscreen
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MDPI and ACS Style

Iosageanu, A.; Ilie, D.; Craciunescu, O.; Seciu-Grama, A.-M.; Oancea, A.; Zarnescu, O.; Moraru, I.; Oancea, F. Effect of Fish Bone Bioactive Peptides on Oxidative, Inflammatory and Pigmentation Processes Triggered by UVB Irradiation in Skin Cells. Molecules 2021, 26, 2691. https://doi.org/10.3390/molecules26092691

AMA Style

Iosageanu A, Ilie D, Craciunescu O, Seciu-Grama A-M, Oancea A, Zarnescu O, Moraru I, Oancea F. Effect of Fish Bone Bioactive Peptides on Oxidative, Inflammatory and Pigmentation Processes Triggered by UVB Irradiation in Skin Cells. Molecules. 2021; 26(9):2691. https://doi.org/10.3390/molecules26092691

Chicago/Turabian Style

Iosageanu, Andreea; Ilie, Daniela; Craciunescu, Oana; Seciu-Grama, Ana-Maria; Oancea, Anca; Zarnescu, Otilia; Moraru, Ionut; Oancea, Florin. 2021. "Effect of Fish Bone Bioactive Peptides on Oxidative, Inflammatory and Pigmentation Processes Triggered by UVB Irradiation in Skin Cells" Molecules 26, no. 9: 2691. https://doi.org/10.3390/molecules26092691

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