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Article

Combining Isotope Dilution and Standard Addition—Elemental Analysis in Complex Samples

1
Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, 38116 Braunschweig, Germany
2
Bundesanstalt für Materialforschung und-Prüfung (BAM), Richard-Willstätter-Str. 11, 12489 Berlin, Germany
3
National Institute of Metrology (Thailand) (NIMT), 3/4-5 Moo 3, Klong 5, Klong Luang, Pathumthani 12120, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Zikri Arslan
Molecules 2021, 26(9), 2649; https://doi.org/10.3390/molecules26092649
Received: 20 April 2021 / Revised: 23 April 2021 / Accepted: 28 April 2021 / Published: 30 April 2021
A new method combining isotope dilution mass spectrometry (IDMS) and standard addition has been developed to determine the mass fractions w of different elements in complex matrices: (a) silicon in aqueous tetramethylammonium hydroxide (TMAH), (b) sulfur in biodiesel fuel, and (c) iron bound to transferrin in human serum. All measurements were carried out using inductively coupled plasma mass spectrometry (ICP–MS). The method requires the gravimetric preparation of several blends (bi)—each consisting of roughly the same masses (mx,i) of the sample solution (x) and my,i of a spike solution (y) plus different masses (mz,i) of a reference solution (z). Only these masses and the isotope ratios (Rb,i) in the blends and reference and spike solutions have to be measured. The derivation of the underlying equations based on linear regression is presented and compared to a related concept reported by Pagliano and Meija. The uncertainties achievable, e.g., in the case of the Si blank in extremely pure TMAH of urel (w(Si)) = 90% (linear regression method, this work) and urel (w(Si)) = 150% (the method reported by Pagliano and Meija) seem to suggest better applicability of the new method in practical use due to the higher robustness of regression analysis. View Full-Text
Keywords: isotope dilution mass spectrometry; standard addition; ICP–MS; blank characterization; silicon; sulfur; transferrin; tetramethylammonium hydroxide; biodiesel fuel; human serum isotope dilution mass spectrometry; standard addition; ICP–MS; blank characterization; silicon; sulfur; transferrin; tetramethylammonium hydroxide; biodiesel fuel; human serum
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MDPI and ACS Style

Brauckmann, C.; Pramann, A.; Rienitz, O.; Schulze, A.; Phukphatthanachai, P.; Vogl, J. Combining Isotope Dilution and Standard Addition—Elemental Analysis in Complex Samples. Molecules 2021, 26, 2649. https://doi.org/10.3390/molecules26092649

AMA Style

Brauckmann C, Pramann A, Rienitz O, Schulze A, Phukphatthanachai P, Vogl J. Combining Isotope Dilution and Standard Addition—Elemental Analysis in Complex Samples. Molecules. 2021; 26(9):2649. https://doi.org/10.3390/molecules26092649

Chicago/Turabian Style

Brauckmann, Christine, Axel Pramann, Olaf Rienitz, Alexander Schulze, Pranee Phukphatthanachai, and Jochen Vogl. 2021. "Combining Isotope Dilution and Standard Addition—Elemental Analysis in Complex Samples" Molecules 26, no. 9: 2649. https://doi.org/10.3390/molecules26092649

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