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Review

Anti-TNF-α Compounds as a Treatment for Depression

by 1 and 1,2,*
1
Department of Clinical Biochemistry and Pharmacology, School for Community Health Professions—Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 8410501, Israel
2
Department of Nursing, School for Community Health Professions—Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 8410501, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Molecules 2021, 26(8), 2368; https://doi.org/10.3390/molecules26082368
Received: 22 March 2021 / Revised: 14 April 2021 / Accepted: 17 April 2021 / Published: 19 April 2021
(This article belongs to the Special Issue Anti-inflammatory Drugs as a Treatment for Psychiatric Disorders)
Millions of people around the world suffer from psychiatric illnesses, causing unbearable burden and immense distress to patients and their families. Accumulating evidence suggests that inflammation may contribute to the pathophysiology of psychiatric disorders such as major depression and bipolar disorder. Copious studies have consistently shown that patients with mood disorders have increased levels of plasma tumor necrosis factor (TNF)-α. Given these findings, selective anti-TNF-α compounds were tested as a potential therapeutic strategy for mood disorders. This mini-review summarizes the results of studies that examined the mood-modulating effects of anti-TNF-α drugs. View Full-Text
Keywords: bipolar disorder; depression; inflammation; pentoxifylline; TNF-α; TNFR bipolar disorder; depression; inflammation; pentoxifylline; TNF-α; TNFR
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MDPI and ACS Style

Uzzan, S.; Azab, A.N. Anti-TNF-α Compounds as a Treatment for Depression. Molecules 2021, 26, 2368. https://doi.org/10.3390/molecules26082368

AMA Style

Uzzan S, Azab AN. Anti-TNF-α Compounds as a Treatment for Depression. Molecules. 2021; 26(8):2368. https://doi.org/10.3390/molecules26082368

Chicago/Turabian Style

Uzzan, Sarit, and Abed N. Azab 2021. "Anti-TNF-α Compounds as a Treatment for Depression" Molecules 26, no. 8: 2368. https://doi.org/10.3390/molecules26082368

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