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Article

Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market

1
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35100 Padova, Italy
2
Unired srl, Via Niccolò Tommaseo 69, 35131 Padova, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Ryszard Amarowicz
Molecules 2021, 26(8), 2222; https://doi.org/10.3390/molecules26082222
Received: 19 March 2021 / Revised: 7 April 2021 / Accepted: 9 April 2021 / Published: 12 April 2021
The use of dietary supplements for the prevention and management of diseases associated with excess of lipids is spreading in Western countries. Supplements containing red yeast rice (RYR) and extracts from Berberis species, characterized, respectively, by the active compounds monacolin K (MK) and berberine (BBR), are sold in pharmacies as over the counter medicines (OTC) and in regular markets without the need of medical prescription and medical surveillance. However, MK is chemically identical to lovastatin, a drug commonly used to treat hypercholesterolemia, and is characterized by the same mechanism of action, pharmacokinetic profile and toxicity. On the other hand, although BBR-containing supplements are considered to be well-tolerated and safe, they frequently show poor standardization of active ingredients, and this could lead to lack of effects. In this work, with the aim to give an overview on the potency of RYR- and BBR-containing supplements available on the Italian market, we analyzed a pool of supplements bought from both local pharmacies and markets. Results confirm the data already published by other authors, showing scarce standardization of bioactives and discrepancy between the doses of bioactives reported by the manufacturers and the amounts resulting from analysis of the same products. Overall, our data represent a further proof that a strict legislation regulating the production and marketing of dietary supplements and a close monitoring of these products by food and drug regulatory organs is mandatory. View Full-Text
Keywords: red yeast rice; monacolins; berberine; dietary supplements; nutraceuticals; mass spectrometry red yeast rice; monacolins; berberine; dietary supplements; nutraceuticals; mass spectrometry
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MDPI and ACS Style

Marcheluzzo, S.; Faggian, M.; Zancato, M.; Peron, G. Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market. Molecules 2021, 26, 2222. https://doi.org/10.3390/molecules26082222

AMA Style

Marcheluzzo S, Faggian M, Zancato M, Peron G. Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market. Molecules. 2021; 26(8):2222. https://doi.org/10.3390/molecules26082222

Chicago/Turabian Style

Marcheluzzo, Sara, Marta Faggian, Mirella Zancato, and Gregorio Peron. 2021. "Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market" Molecules 26, no. 8: 2222. https://doi.org/10.3390/molecules26082222

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