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Article

Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms

1
Stokes Laboratories, School of Engineering, Bernal Institute and AMBER, University of Limerick, V94 T9PX Limerick, Ireland
2
Pharmaceutical Centre (SSPC), University of Limerick, V94 T9PX Limerick, Ireland
*
Author to whom correspondence should be addressed.
Academic Editors: Rui L. Reis and Már Másson
Molecules 2021, 26(6), 1593; https://doi.org/10.3390/molecules26061593
Received: 9 February 2021 / Revised: 19 February 2021 / Accepted: 10 March 2021 / Published: 13 March 2021
(This article belongs to the Special Issue Lignocellulosic Materials)
Nowadays, sustainable materials are receiving significant attention due to the fact that they will be crucial for the development of the next generation of products and devices. In the present work, hydrogels have been successfully synthesized using lignin which is non-valorized biopolymer from the paper industry. Hydrogels were prepared via crosslinking with Poly(ethylene) glycol diglycidyl ether (PEGDGE). Different crosslinker ratios were used to determine their influence on the structural and chemical properties of the resulting hydrogels. It has been found that pore size was reduced by increasing crosslinker amount. The greater crosslinking density increased the swelling capacity of the hydrogels due to the presence of more hydrophilic groups in the hydrogel network. Paracetamol release test showed higher drug diffusion for hydrogels produced with a ratio lignin:PEGDGE 1:1. The obtained results demonstrate that the proposed approach is a promising route to utilize lignocellulose waste for producing porous materials for advanced biomedical applications in the pharmacy industry. View Full-Text
Keywords: lignin; hydrogels; crosslinking; drug release lignin; hydrogels; crosslinking; drug release
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MDPI and ACS Style

Culebras, M.; Pishnamazi, M.; Walker, G.M.; Collins, M.N. Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms. Molecules 2021, 26, 1593. https://doi.org/10.3390/molecules26061593

AMA Style

Culebras M, Pishnamazi M, Walker GM, Collins MN. Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms. Molecules. 2021; 26(6):1593. https://doi.org/10.3390/molecules26061593

Chicago/Turabian Style

Culebras, Mario, Mahboubeh Pishnamazi, Gavin M. Walker, and Maurice N. Collins. 2021. "Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms" Molecules 26, no. 6: 1593. https://doi.org/10.3390/molecules26061593

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