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Article

Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties

Department of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020 Tyczyn, Poland
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Academic Editors: Giuseppe Caruso, Nicolò Musso and Claudia Giuseppina Fresta
Molecules 2021, 26(4), 802; https://doi.org/10.3390/molecules26040802
Received: 30 December 2020 / Revised: 27 January 2021 / Accepted: 31 January 2021 / Published: 4 February 2021
The skin is an organ that is constantly exposed to many external factors that can affect its structure and function. Due to the presence of different cannabinoid receptors on many types of skin cells, cannabinoids can interact directly with them. Therefore, as part of this work, the impact of two types of Cannabis sativa L. herb extracts on keratinocytes and fibroblasts was assessed. The content of biologically active compounds such as phenols, flavonoids, chlorophylls and cannabinoids was evaluated. The antioxidant capacity of prepared extracts using the DPPH radical, H2DCFDA probe and measurement of superoxide dismutase activity was also assessed. The cytotoxicity of hemp extracts was determined using the Alamar Blue, Neutral Red and LDH assays. The ability of the extracts to inhibit the activity of matrix metalloproteinases, collagenase and elastase, was assessed. Preparations of model hydrogels were also prepared and their effect on transepidermal water loss and skin hydration was measured. The obtained results indicate that hemp extracts can be a valuable source of biologically active substances that reduce oxidative stress, inhibit skin aging processes and positively affect the viability of skin cells. The analysis also showed that hydrogels based on cannabis extracts have a positive effect on skin hydration. View Full-Text
Keywords: Cannabis sativa L.; antioxidants; metalloproteinase inhibitors; cytotoxicity; skin cells; hydrogel Cannabis sativa L.; antioxidants; metalloproteinase inhibitors; cytotoxicity; skin cells; hydrogel
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MDPI and ACS Style

Zagórska-Dziok, M.; Bujak, T.; Ziemlewska, A.; Nizioł-Łukaszewska, Z. Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties. Molecules 2021, 26, 802. https://doi.org/10.3390/molecules26040802

AMA Style

Zagórska-Dziok M, Bujak T, Ziemlewska A, Nizioł-Łukaszewska Z. Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties. Molecules. 2021; 26(4):802. https://doi.org/10.3390/molecules26040802

Chicago/Turabian Style

Zagórska-Dziok, Martyna, Tomasz Bujak, Aleksandra Ziemlewska, and Zofia Nizioł-Łukaszewska. 2021. "Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties" Molecules 26, no. 4: 802. https://doi.org/10.3390/molecules26040802

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