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Review

The Protective Role of Butyrate against Obesity and Obesity-Related Diseases

1
Department of Translational Medical Science, University of Naples Federico II, 80131 Naples, Italy
2
ImmunoNutriton Lab at CEINGE Advanced Biotechnologies, University of Naples Federico II, 80131 Naples, Italy
3
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy
4
European Laboratory for the Investigation of Food Induced Diseases (ELFID), University of Naples Federico II, 80131 Naples, Italy
5
Task Force on Microbiome Studies, University of Naples Federico II, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Ryszard Amarowicz
Molecules 2021, 26(3), 682; https://doi.org/10.3390/molecules26030682
Received: 7 January 2021 / Revised: 21 January 2021 / Accepted: 25 January 2021 / Published: 28 January 2021
Worldwide obesity is a public health concern that has reached pandemic levels. Obesity is the major predisposing factor to comorbidities, including type 2 diabetes, cardiovascular diseases, dyslipidemia, and non-alcoholic fatty liver disease. The common forms of obesity are multifactorial and derive from a complex interplay of environmental changes and the individual genetic predisposition. Increasing evidence suggest a pivotal role played by alterations of gut microbiota (GM) that could represent the causative link between environmental factors and onset of obesity. The beneficial effects of GM are mainly mediated by the secretion of various metabolites. Short-chain fatty acids (SCFAs) acetate, propionate and butyrate are small organic metabolites produced by fermentation of dietary fibers and resistant starch with vast beneficial effects in energy metabolism, intestinal homeostasis and immune responses regulation. An aberrant production of SCFAs has emerged in obesity and metabolic diseases. Among SCFAs, butyrate emerged because it might have a potential in alleviating obesity and related comorbidities. Here we reviewed the preclinical and clinical data that contribute to explain the role of butyrate in this context, highlighting its crucial contribute in the diet-GM-host health axis. View Full-Text
Keywords: short-chain fatty acids; butyric acid; metabolic diseases; gut microbiota short-chain fatty acids; butyric acid; metabolic diseases; gut microbiota
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MDPI and ACS Style

Coppola, S.; Avagliano, C.; Calignano, A.; Berni Canani, R. The Protective Role of Butyrate against Obesity and Obesity-Related Diseases. Molecules 2021, 26, 682. https://doi.org/10.3390/molecules26030682

AMA Style

Coppola S, Avagliano C, Calignano A, Berni Canani R. The Protective Role of Butyrate against Obesity and Obesity-Related Diseases. Molecules. 2021; 26(3):682. https://doi.org/10.3390/molecules26030682

Chicago/Turabian Style

Coppola, Serena; Avagliano, Carmen; Calignano, Antonio; Berni Canani, Roberto. 2021. "The Protective Role of Butyrate against Obesity and Obesity-Related Diseases" Molecules 26, no. 3: 682. https://doi.org/10.3390/molecules26030682

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