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Article

Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer’s Disease

by
Paige Grant
1,
Jitendra Kumar
1,
Satyabrata Kar
2 and
Michael Overduin
1,*
1
Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada
2
Centre for Prions and Protein Folding Diseases, Department of Medicine (Neurology), University of Alberta, Edmonton, AB T6G 2MB, Canada
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(24), 7669; https://doi.org/10.3390/molecules26247669
Submission received: 16 November 2021 / Revised: 14 December 2021 / Accepted: 16 December 2021 / Published: 18 December 2021
(This article belongs to the Special Issue New Advances in the Development of Kinase Inhibitors)
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Abstract

Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Despite extensive research and targeting of the main molecular components of the disease, beta-amyloid (Aβ) and tau, there are currently no treatments that alter the progression of the disease. Here, we examine the effects of two specific kinase inhibitors for calcium/calmodulin-dependent protein kinase type 1D (CaMK1D) on Aβ-mediated toxicity, using mouse primary cortical neurons. Tau hyperphosphorylation and cell death were used as AD indicators. These specific inhibitors were found to prevent Aβ induced tau hyperphosphorylation in culture, but were not able to protect cells from Aβ induced toxicity. While inhibitors were able to alter AD pathology in cell culture, they were insufficient to prevent cell death. With further research and development, these inhibitors could contribute to a multi-drug strategy to combat AD.
Keywords: Alzheimer’s disease; kinase inhibitor; CaMK1D; beta-amyloid; tau phosphorylation Alzheimer’s disease; kinase inhibitor; CaMK1D; beta-amyloid; tau phosphorylation
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MDPI and ACS Style

Grant, P.; Kumar, J.; Kar, S.; Overduin, M. Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer’s Disease. Molecules 2021, 26, 7669. https://doi.org/10.3390/molecules26247669

AMA Style

Grant P, Kumar J, Kar S, Overduin M. Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer’s Disease. Molecules. 2021; 26(24):7669. https://doi.org/10.3390/molecules26247669

Chicago/Turabian Style

Grant, Paige, Jitendra Kumar, Satyabrata Kar, and Michael Overduin. 2021. "Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer’s Disease" Molecules 26, no. 24: 7669. https://doi.org/10.3390/molecules26247669

APA Style

Grant, P., Kumar, J., Kar, S., & Overduin, M. (2021). Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer’s Disease. Molecules, 26(24), 7669. https://doi.org/10.3390/molecules26247669

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