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Article

Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles

by 1, 1, 1, 1 and 1,2,*
1
Anhui Province Key Laboratory of Chemistry for Inorganic, Organic Hybrid Functionalized Materials, College of Chemistry & Chemical Engineering, Anhui University, Hefei 230601, China
2
Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University), Ministry of Education, Hefei 230601, China
*
Author to whom correspondence should be addressed.
Academic Editors: Lei Zhou and Steven Bloom
Molecules 2021, 26(22), 6843; https://doi.org/10.3390/molecules26226843
Received: 28 October 2021 / Revised: 8 November 2021 / Accepted: 11 November 2021 / Published: 12 November 2021
An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules. View Full-Text
Keywords: benzothiazolines; photochemistry; heterocycles benzothiazolines; photochemistry; heterocycles
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MDPI and ACS Style

He, X.-K.; Lu, J.; Ye, H.-B.; Li, L.; Xuan, J. Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles. Molecules 2021, 26, 6843. https://doi.org/10.3390/molecules26226843

AMA Style

He X-K, Lu J, Ye H-B, Li L, Xuan J. Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles. Molecules. 2021; 26(22):6843. https://doi.org/10.3390/molecules26226843

Chicago/Turabian Style

He, Xiang-Kui, Juan Lu, Hai-Bing Ye, Lei Li, and Jun Xuan. 2021. "Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles" Molecules 26, no. 22: 6843. https://doi.org/10.3390/molecules26226843

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