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Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases

1
Quality Management Division, Higuchi Inc. Minato-ku, Tokyo 108-0075, Japan
2
Institute of Microbial Chemistry (BIKAKEN), Microbial Chemistry Research Foundation, Numazu, Shizuoka 410-0301, Japan
3
Shizuoka Eiwa Gakuin University Junior College, Suruga-ku, Shizuoka 422-8545, Japan
4
Tea Science Research Center, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Saverio Bettuzzi
Molecules 2021, 26(2), 415; https://doi.org/10.3390/molecules26020415
Received: 28 December 2020 / Revised: 12 January 2021 / Accepted: 12 January 2021 / Published: 14 January 2021
(This article belongs to the Special Issue Catechins in Human Health 2020)
Many observational and clinical studies have shown that consumption of diets rich in plant polyphenols have beneficial effects on various diseases such as cancer, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases (NDDs). Animal and cellular studies have indicated that these polyphenolic compounds contribute to such effects. The representative polyphenols are epigallocatechin-3-O-gallate in tea, chlorogenic acids in coffee, resveratrol in wine, and curcumin in curry. The results of human studies have suggested the beneficial effects of consumption of these foods on NDDs including Alzheimer’s and Parkinson’s diseases, and cellular animal experiments have provided molecular basis to indicate contribution of these representative polyphenols to these effects. This article provides updated information on the effects of these foods and their polyphenols on NDDs with discussions on mechanistic aspects of their actions mainly based on the findings derived from basic experiments. View Full-Text
Keywords: polyphenols; EGCG; chlorogenic acid; resveratrol; curcumin; NDD; ROS; AMPK; NF-κB polyphenols; EGCG; chlorogenic acid; resveratrol; curcumin; NDD; ROS; AMPK; NF-κB
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MDPI and ACS Style

Fukutomi, R.; Ohishi, T.; Koyama, Y.; Pervin, M.; Nakamura, Y.; Isemura, M. Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases. Molecules 2021, 26, 415. https://doi.org/10.3390/molecules26020415

AMA Style

Fukutomi R, Ohishi T, Koyama Y, Pervin M, Nakamura Y, Isemura M. Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases. Molecules. 2021; 26(2):415. https://doi.org/10.3390/molecules26020415

Chicago/Turabian Style

Fukutomi, Ryuuta, Tomokazu Ohishi, Yu Koyama, Monira Pervin, Yoriyuki Nakamura, and Mamoru Isemura. 2021. "Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases" Molecules 26, no. 2: 415. https://doi.org/10.3390/molecules26020415

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