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Article

Differential Protein Expression in Exponential and Stationary Growth Phases of Mycobacterium avium subsp. hominissuis 104

1
Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
2
Leprosy Research Center, Department of Mycobacteriology, National Institute of Infectious Diseases, Tokyo 189-0002, Japan
3
Department of Bacteriology, Niigata University Graduate School of Medicine, Niigata 951-8510, Japan
*
Authors to whom correspondence should be addressed.
Molecules 2021, 26(2), 305; https://doi.org/10.3390/molecules26020305
Received: 6 December 2020 / Revised: 29 December 2020 / Accepted: 30 December 2020 / Published: 8 January 2021
Mycobacterium avium complex (MAC) is the most common non-tuberculous mycobacterium (NTM) and causes different types of pulmonary diseases. While genomic and transcriptomic analysis of Mycobacterium avium 104 (M. avium 104) has been extensive, little is known about the proteomics of M. avium 104. We utilized proteomics technology to analyze the changes in the whole proteome of M. avium 104 during exponential and stationary growth phases. We found 12 dys-regulated proteins; the up-regulated protein hits in the stationary phase were involved in aminopeptidase, choline dehydrogenase, oxidoreductase, and ATP binding, while the down-regulated proteins in the stationary phase were acetyl-CoA acetyltransferase, universal stress protein, catalase peroxidase, and elongation factor (Tu). The differently expressed proteins between exponential and stationary phases were implicated in metabolism and stress response, pointing to the functional adaptation of the cells to the environment. Proteomic analysis in different growth phases could participate in understanding the course of infection, the mechanisms of virulence, the means of survival, and the possible targets for treatment. View Full-Text
Keywords: Mycobacterium avium 104; proteins; proteomics; exponential; stationary; growth phases Mycobacterium avium 104; proteins; proteomics; exponential; stationary; growth phases
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MDPI and ACS Style

Enany, S.; Ato, M.; Matsumoto, S. Differential Protein Expression in Exponential and Stationary Growth Phases of Mycobacterium avium subsp. hominissuis 104. Molecules 2021, 26, 305. https://doi.org/10.3390/molecules26020305

AMA Style

Enany S, Ato M, Matsumoto S. Differential Protein Expression in Exponential and Stationary Growth Phases of Mycobacterium avium subsp. hominissuis 104. Molecules. 2021; 26(2):305. https://doi.org/10.3390/molecules26020305

Chicago/Turabian Style

Enany, Shymaa, Manabu Ato, and Sohkichi Matsumoto. 2021. "Differential Protein Expression in Exponential and Stationary Growth Phases of Mycobacterium avium subsp. hominissuis 104" Molecules 26, no. 2: 305. https://doi.org/10.3390/molecules26020305

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