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Article

Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

1
Medicinal Chemistry Research Group, Research Centre for Natural Sciences, H-1117 Budapest, Hungary
2
Lendület Artificial Transporters Research Group, Research Centre for Natural Sciences, H-1117 Budapest, Hungary
*
Authors to whom correspondence should be addressed.
Molecules 2021, 26(2), 303; https://doi.org/10.3390/molecules26020303
Received: 15 December 2020 / Revised: 4 January 2021 / Accepted: 7 January 2021 / Published: 8 January 2021
(This article belongs to the Special Issue Advances in Flow Chemistry)
We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur. View Full-Text
Keywords: continuous flow; sulfur; aqueous polysulfide solution; thiourea; multicomponent reaction continuous flow; sulfur; aqueous polysulfide solution; thiourea; multicomponent reaction
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MDPI and ACS Style

Németh, A.G.; Szabó, R.; Orsy, G.; Mándity, I.M.; Keserű, G.M.; Ábrányi-Balogh, P. Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution. Molecules 2021, 26, 303. https://doi.org/10.3390/molecules26020303

AMA Style

Németh AG, Szabó R, Orsy G, Mándity IM, Keserű GM, Ábrányi-Balogh P. Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution. Molecules. 2021; 26(2):303. https://doi.org/10.3390/molecules26020303

Chicago/Turabian Style

Németh, András G., Renáta Szabó, György Orsy, István M. Mándity, György M. Keserű, and Péter Ábrányi-Balogh. 2021. "Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution" Molecules 26, no. 2: 303. https://doi.org/10.3390/molecules26020303

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