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Review

Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review

by 1,2, 1,2,3, 1,2, 1,2, 1,2,4, 1,2, 1,2,*, 1,2,* and 1,2,*
1
School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China
2
Key Laboratory of Element Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, China
3
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
4
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Maria José U. Ferreira
Molecules 2021, 26(19), 5792; https://doi.org/10.3390/molecules26195792
Received: 5 June 2021 / Revised: 18 September 2021 / Accepted: 20 September 2021 / Published: 24 September 2021
Malignant tumors are life-threatening, and chemotherapy is one of the common treatment methods. However, there are often many factors that contribute to the failure of chemotherapy. The multidrug resistance of cancer cells during chemotherapy has been reported, since tumor cells’ sensitivity decreases over time. To overcome these problems, extensive studies have been conducted to reverse drug resistance in tumor cells. Elemene, an extract of the natural drug Curcuma wenyujin, has been found to reverse drug resistance and sensitize cancer cells to chemotherapy. Mechanisms by which elemene reverses tumor resistance include inhibiting the efflux of ATP binding cassette subfamily B member 1(ABCB1) transporter, reducing the transmission of exosomes, inducing apoptosis and autophagy, regulating the expression of key genes and proteins in various signaling pathways, blocking the cell cycle, inhibiting stemness, epithelial–mesenchymal transition, and so on. In this paper, the mechanisms of elemene’s reversal of drug resistance are comprehensively reviewed. View Full-Text
Keywords: elemene; multidrug resistance; mechanism; tumor elemene; multidrug resistance; mechanism; tumor
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MDPI and ACS Style

Tan, T.; Li, J.; Luo, R.; Wang, R.; Yin, L.; Liu, M.; Zeng, Y.; Zeng, Z.; Xie, T. Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review. Molecules 2021, 26, 5792. https://doi.org/10.3390/molecules26195792

AMA Style

Tan T, Li J, Luo R, Wang R, Yin L, Liu M, Zeng Y, Zeng Z, Xie T. Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review. Molecules. 2021; 26(19):5792. https://doi.org/10.3390/molecules26195792

Chicago/Turabian Style

Tan, Tiantian, Jie Li, Ruhua Luo, Rongrong Wang, Liyan Yin, Mengmeng Liu, Yiying Zeng, Zhaowu Zeng, and Tian Xie. 2021. "Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review" Molecules 26, no. 19: 5792. https://doi.org/10.3390/molecules26195792

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