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Article

Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini

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Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, 51000 Rijeka, Croatia
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Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
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Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) UMR CNRS 7378—Institut de Chimie de Picardie FR 3085, Université de Picardie Jules Verne, 33 Rue Saint Leu, 80039 Amiens, France
4
Faculty of Health Studies, University of Rijeka, Viktora Cara Emina 5, 51000 Rijeka, Croatia
*
Authors to whom correspondence should be addressed.
Academic Editor: Vincenzo De Feo
Molecules 2021, 26(19), 5751; https://doi.org/10.3390/molecules26195751
Received: 2 September 2021 / Revised: 17 September 2021 / Accepted: 19 September 2021 / Published: 23 September 2021
(This article belongs to the Special Issue Translational Approach to Antitumor Drugs - 2nd Edition)
Due to sedentary lifestyle and harsh environmental conditions, gorgonian coral extracts are recognized as a rich source of novel compounds with various biological activities, of interest to the pharmaceutical and cosmetic industries. The presented study aimed to perform chemical screening of organic extracts and semi-purified fractions obtained from the common Adriatic gorgonian, sea fan, Eunicella cavolini (Koch, 1887) and explore its abilities to exert different biological effects in vitro. Qualitative chemical evaluation revealed the presence of several classes of secondary metabolites extended with mass spectrometry analysis and tentative dereplication by using Global Natural Product Social Molecular Networking online platform (GNPS). Furthermore, fractions F4 and F3 showed the highest phenolic (3.28 ± 0.04 mg GAE/g sample) and carotene (23.11 ± 2.48 mg β-CA/g sample) content, respectively. The fraction F3 inhibited 50% of DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) and ABTS (2,2′-azino-bis (3-ethylbenzthiazolin-6-yl) sulfonic acid) radicals at the concentrations of 767.09 ± 11.57 and 157.16 ± 10.83 µg/mL, respectively. The highest anti-inflammatory potential was exhibited by F2 (IC50 = 198.70 ± 28.77 µg/mL) regarding the inhibition of albumin denaturation and F1 (IC50 = 254.49 ± 49.17 µg/mL) in terms of soybean lipoxygenase inhibition. In addition, the most pronounced antiproliferative effects were observed for all samples (IC50 ranging from 0.82 ± 0.14–231.18 ± 46.13 µg/mL) against several carcinoma cell lines, but also towards non-transformed human fibroblasts pointing to a generally cytotoxic effect. In addition, the antibacterial activity was tested by broth microdilution assay against three human pathogenic bacteria: Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The latter was the most affected by fractions F2 and F3. Finally, further purification, isolation and characterization of pure compounds from the most active fractions are under investigation. View Full-Text
Keywords: biological activities; biological screening; Eunicella cavolini; gorgonian corals; organic extracts biological activities; biological screening; Eunicella cavolini; gorgonian corals; organic extracts
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MDPI and ACS Style

Matulja, D.; Grbčić, P.; Bojanić, K.; Topić-Popović, N.; Čož-Rakovac, R.; Laclef, S.; Šmuc, T.; Jović, O.; Marković, D.; Pavelić, S.K. Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini. Molecules 2021, 26, 5751. https://doi.org/10.3390/molecules26195751

AMA Style

Matulja D, Grbčić P, Bojanić K, Topić-Popović N, Čož-Rakovac R, Laclef S, Šmuc T, Jović O, Marković D, Pavelić SK. Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini. Molecules. 2021; 26(19):5751. https://doi.org/10.3390/molecules26195751

Chicago/Turabian Style

Matulja, Dario, Petra Grbčić, Krunoslav Bojanić, Natalija Topić-Popović, Rozelindra Čož-Rakovac, Sylvain Laclef, Tomislav Šmuc, Ozren Jović, Dean Marković, and Sandra Kraljević Pavelić. 2021. "Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, Eunicella cavolini" Molecules 26, no. 19: 5751. https://doi.org/10.3390/molecules26195751

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