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Article

Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures

1
Institute of Chemical Sciences and Technologies “Giulio Natta”, National Research Council, Via Mario Bianco 9, 20131 Milan, Italy
2
Institute of Agricultural Biology and Biotechnology, National Research Council, Via Bassini 15, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Toyonobu Usuki, Akira Kawamura and Masaru Hashimoto
Molecules 2021, 26(17), 5189; https://doi.org/10.3390/molecules26175189
Received: 29 July 2021 / Revised: 19 August 2021 / Accepted: 23 August 2021 / Published: 27 August 2021
(This article belongs to the Special Issue Recent Advances on Natural Product Research)
Lignans are the main secondary metabolites synthetized by Linum species as plant defense molecules. They are also valuable for human health, in particular, for their potent antiviral and antineoplastic properties. In this study, the adventitious root cultures of three Linum species (L. flavum, L. mucronatum and L. dolomiticum) were developed to produce aryltetralin lignans. The effect of two elicitors, methyl jasmonate and coronatine, on aryltetralin lignans production was also evaluated. The adventitious root cultures from L. dolomiticum were obtained and analyzed for the first time and resulted as the best producer for all the aryltetralins highlighted in this system: Podophyllotoxin, 6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin-7-O-β-glucoside, the last showing a productivity of 92.6 mg/g DW. The two elicitors differently affected the production of the 6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin-7-O-β-glucoside. View Full-Text
Keywords: Linum; aryltetralin lignans; 6-methoxypodophyllotoxin; elicitor; NMR; methyl jasmonate; coronatine Linum; aryltetralin lignans; 6-methoxypodophyllotoxin; elicitor; NMR; methyl jasmonate; coronatine
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MDPI and ACS Style

Alfieri, M.; Mascheretti, I.; Dougué Kentsop, R.A.; Consonni, R.; Locatelli, F.; Mattana, M.; Ottolina, G. Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures. Molecules 2021, 26, 5189. https://doi.org/10.3390/molecules26175189

AMA Style

Alfieri M, Mascheretti I, Dougué Kentsop RA, Consonni R, Locatelli F, Mattana M, Ottolina G. Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures. Molecules. 2021; 26(17):5189. https://doi.org/10.3390/molecules26175189

Chicago/Turabian Style

Alfieri, Michela, Iride Mascheretti, Roméo A. Dougué Kentsop, Roberto Consonni, Franca Locatelli, Monica Mattana, and Gianluca Ottolina. 2021. "Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures" Molecules 26, no. 17: 5189. https://doi.org/10.3390/molecules26175189

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