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Review

New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes

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Faculdade de Ciências, BioISI-Biosystems and Integrative Sciences Institute, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal
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CIC nanoGUNE BRTA, Tolosa Hiribidea 76, Euskadi, 20018 Donostia-San Sebastián, Spain
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Polimero eta Material Aurreratuak, Fisika, Kimika eta Teknologia Saila, Kimika Fakultatea, Euskal Herriko Unibertsitatea (UPV/EHU), Paseo Manuel de Lardizabal 3, 20018 Donostia-San Sebastián, Spain
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Laboratoire de Chimie Inorganique, LR17ES07, Faculté de Sciences de Sfax, Université de Sfax, Sfax 3000, Tunisia
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Donostia International Physics Center (DIPC), Paseo Manuel de Lardizabal 4, 20018 Donostia-San Sebastián, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Angelo Spinello, Giampaolo Barone and Antonio Monari
Molecules 2021, 26(16), 4737; https://doi.org/10.3390/molecules26164737
Received: 30 June 2021 / Revised: 28 July 2021 / Accepted: 29 July 2021 / Published: 5 August 2021
This work provides new insights from our team regarding advances in targeting canonical and non-canonical nucleic acid structures. This modality of medical treatment is used as a form of molecular medicine specifically against the growth of cancer cells. Nevertheless, because of increasing concerns about bacterial antibiotic resistance, this medical strategy is also being explored in this field. Up to three strategies for the use of DNA as target have been studied in our research lines during the last few years: (1) the intercalation of phenanthroline derivatives with duplex DNA; (2) the interaction of metal complexes containing phenanthroline with G-quadruplexes; and (3) the activity of Mo polyoxometalates and other Mo-oxo species as artificial phosphoesterases to catalyze the hydrolysis of phosphoester bonds in DNA. We demonstrate some promising computational results concerning the favorable interaction of these small molecules with DNA that could correspond to cytotoxic effects against tumoral cells and microorganisms. Therefore, our results open the door for the pharmaceutical and medical applications of the compounds we propose. View Full-Text
Keywords: artificial phosphoesterases; DNA; G-quadruplexes; intercalation; LS-DFT; Mo-oxo species; phenanthroline derivatives; phosphoester hydrolysis catalysis; polyoxometalates; weak interactions artificial phosphoesterases; DNA; G-quadruplexes; intercalation; LS-DFT; Mo-oxo species; phenanthroline derivatives; phosphoester hydrolysis catalysis; polyoxometalates; weak interactions
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MDPI and ACS Style

Sánchez-González, Á.; Bandeira, N.A.G.; Ortiz de Luzuriaga, I.; Martins, F.F.; Elleuchi, S.; Jarraya, K.; Lanuza, J.; Lopez, X.; Calhorda, M.J.; Gil, A. New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes. Molecules 2021, 26, 4737. https://doi.org/10.3390/molecules26164737

AMA Style

Sánchez-González Á, Bandeira NAG, Ortiz de Luzuriaga I, Martins FF, Elleuchi S, Jarraya K, Lanuza J, Lopez X, Calhorda MJ, Gil A. New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes. Molecules. 2021; 26(16):4737. https://doi.org/10.3390/molecules26164737

Chicago/Turabian Style

Sánchez-González, Ángel, Nuno A.G. Bandeira, Iker Ortiz de Luzuriaga, Frederico F. Martins, Sawssen Elleuchi, Khaled Jarraya, Jose Lanuza, Xabier Lopez, Maria J. Calhorda, and Adrià Gil. 2021. "New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes" Molecules 26, no. 16: 4737. https://doi.org/10.3390/molecules26164737

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