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Review

A Multidisciplinary Approach to Coronavirus Disease (COVID-19)

by
Aliye Gediz Erturk
1,
Arzu Sahin
2,
Ebru Bati Ay
3,
Emel Pelit
4,
Emine Bagdatli
1,*,
Irem Kulu
5,
Melek Gul
6,*,
Seda Mesci
7,
Serpil Eryilmaz
8,
Sirin Oba Ilter
9 and
Tuba Yildirim
10
1
Department of Chemistry, Faculty of Arts and Sciences, Ordu University, Altınordu, Ordu 52200, Turkey
2
Department of Basic Medical Sciences—Physiology, Faculty of Medicine, Uşak University, 1-EylulUşak 64000, Turkey
3
Department of Plant and Animal Production, Suluova Vocational School, Amasya University, Suluova, Amasya 05100, Turkey
4
Department of Chemistry, Faculty of Arts and Sciences, Kırklareli University, Kırklareli 39000, Turkey
5
Department of Chemistry, Faculty of Basic Sciences, Gebze Technical University, Kocaeli 41400, Turkey
6
Department of Chemistry, Faculty of Arts and Sciences, Amasya University, Ipekkoy, Amasya 05100, Turkey
7
Scientific Technical Application and Research Center, Hitit University, Çorum 19030, Turkey
8
Department of Physics, Faculty of Arts and Sciences, Amasya University, Ipekkoy, Amasya 05100, Turkey
9
Food Processing Department, Suluova Vocational School, Amasya University, Suluova, Amasya 05100, Turkey
10
Department of Biology, Faculty of Arts and Sciences, Amasya University, Ipekkoy, Amasya 05100, Turkey
*
Authors to whom correspondence should be addressed.
Molecules 2021, 26(12), 3526; https://doi.org/10.3390/molecules26123526
Submission received: 28 April 2021 / Revised: 4 June 2021 / Accepted: 4 June 2021 / Published: 9 June 2021
(This article belongs to the Special Issue Selected Papers from the 6th International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-6))
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Abstract

Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the world has been to direct their time to research this subject. In this review, we highlight chemical studies and therapeutic approaches to overcome COVID-19 with seven different sections. These sections are the structure and mechanism of action of SARS-CoV-2, immunotherapy and vaccine, computer-aided drug design, repurposing therapeutics for COVID-19, synthesis of new molecular structures against COVID-19, food safety/security and functional food components, and potential natural products against COVID-19. In this work, we aimed to screen all the newly synthesized compounds, repurposing chemicals covering antiviral, anti-inflammatory, antibacterial, antiparasitic, anticancer, antipsychotic, and antihistamine compounds against COVID-19. We also highlight computer-aided approaches to develop an anti-COVID-19 molecule. We explain that some phytochemicals and dietary supplements have been identified as antiviral bioproducts, which have almost been successfully tested against COVID-19. In addition, we present immunotherapy types, targets, immunotherapy and inflammation/mutations of the virus, immune response, and vaccine issues.
Keywords: SARS-CoV-2; COVID-19; cytokine storm; immunotherapy; vaccine development; in-silico research; small drugs; repurposing drugs; dietary supplements; natural products SARS-CoV-2; COVID-19; cytokine storm; immunotherapy; vaccine development; in-silico research; small drugs; repurposing drugs; dietary supplements; natural products
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MDPI and ACS Style

Gediz Erturk, A.; Sahin, A.; Bati Ay, E.; Pelit, E.; Bagdatli, E.; Kulu, I.; Gul, M.; Mesci, S.; Eryilmaz, S.; Oba Ilter, S.; et al. A Multidisciplinary Approach to Coronavirus Disease (COVID-19). Molecules 2021, 26, 3526. https://doi.org/10.3390/molecules26123526

AMA Style

Gediz Erturk A, Sahin A, Bati Ay E, Pelit E, Bagdatli E, Kulu I, Gul M, Mesci S, Eryilmaz S, Oba Ilter S, et al. A Multidisciplinary Approach to Coronavirus Disease (COVID-19). Molecules. 2021; 26(12):3526. https://doi.org/10.3390/molecules26123526

Chicago/Turabian Style

Gediz Erturk, Aliye, Arzu Sahin, Ebru Bati Ay, Emel Pelit, Emine Bagdatli, Irem Kulu, Melek Gul, Seda Mesci, Serpil Eryilmaz, Sirin Oba Ilter, and et al. 2021. "A Multidisciplinary Approach to Coronavirus Disease (COVID-19)" Molecules 26, no. 12: 3526. https://doi.org/10.3390/molecules26123526

APA Style

Gediz Erturk, A., Sahin, A., Bati Ay, E., Pelit, E., Bagdatli, E., Kulu, I., Gul, M., Mesci, S., Eryilmaz, S., Oba Ilter, S., & Yildirim, T. (2021). A Multidisciplinary Approach to Coronavirus Disease (COVID-19). Molecules, 26(12), 3526. https://doi.org/10.3390/molecules26123526

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