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Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues

Research Genetic Cancer Centre S.A. Industrial Area of Florina, GR53100 Florina, Greece
Research Genetic Cancer Centre International GmbH, Baarerstrasse, 95, 6301 Zug, Switzerland
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Molecules 2021, 26(11), 3461;
Received: 5 May 2021 / Revised: 26 May 2021 / Accepted: 2 June 2021 / Published: 7 June 2021
(This article belongs to the Section Medicinal Chemistry)
Despite the fact that COVID-19 vaccines are already available on the market, there have not been any effective FDA-approved drugs to treat this disease. There are several already known drugs that through drug repositioning have shown an inhibitory activity against SARS-CoV-2 RNA-dependent RNA polymerase. These drugs are included in the family of nucleoside analogues. In our efforts, we synthesized a group of new nucleoside analogues, which are modified at the sugar moiety that is replaced by a quinazoline entity. Different nucleobase derivatives are used in order to increase the inhibition. Five new nucleoside analogues were evaluated with in vitro assays for targeting polymerase of SARS-CoV-2. View Full-Text
Keywords: nucleoside derivatives; COVID-19; quinazoline moiety nucleoside derivatives; COVID-19; quinazoline moiety
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MDPI and ACS Style

Daikopoulou, V.; Apostolou, P.; Mourati, S.; Vlachou, I.; Gougousi, M.; Papasotiriou, I. Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues. Molecules 2021, 26, 3461.

AMA Style

Daikopoulou V, Apostolou P, Mourati S, Vlachou I, Gougousi M, Papasotiriou I. Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues. Molecules. 2021; 26(11):3461.

Chicago/Turabian Style

Daikopoulou, Vasiliki, Panagiotis Apostolou, Sofia Mourati, Ioanna Vlachou, Maria Gougousi, and Ioannis Papasotiriou. 2021. "Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues" Molecules 26, no. 11: 3461.

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