Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues
1
Research Genetic Cancer Centre S.A. Industrial Area of Florina, GR53100 Florina, Greece
2
Research Genetic Cancer Centre International GmbH, Baarerstrasse, 95, 6301 Zug, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Molecules 2021, 26(11), 3461; https://doi.org/10.3390/molecules26113461
Received: 5 May 2021
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Revised: 26 May 2021
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Accepted: 2 June 2021
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Published: 7 June 2021
(This article belongs to the Section Medicinal Chemistry)
Despite the fact that COVID-19 vaccines are already available on the market, there have not been any effective FDA-approved drugs to treat this disease. There are several already known drugs that through drug repositioning have shown an inhibitory activity against SARS-CoV-2 RNA-dependent RNA polymerase. These drugs are included in the family of nucleoside analogues. In our efforts, we synthesized a group of new nucleoside analogues, which are modified at the sugar moiety that is replaced by a quinazoline entity. Different nucleobase derivatives are used in order to increase the inhibition. Five new nucleoside analogues were evaluated with in vitro assays for targeting polymerase of SARS-CoV-2.
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Keywords:
nucleoside derivatives; COVID-19; quinazoline moiety
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MDPI and ACS Style
Daikopoulou, V.; Apostolou, P.; Mourati, S.; Vlachou, I.; Gougousi, M.; Papasotiriou, I. Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues. Molecules 2021, 26, 3461. https://doi.org/10.3390/molecules26113461
AMA Style
Daikopoulou V, Apostolou P, Mourati S, Vlachou I, Gougousi M, Papasotiriou I. Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues. Molecules. 2021; 26(11):3461. https://doi.org/10.3390/molecules26113461
Chicago/Turabian StyleDaikopoulou, Vasiliki, Panagiotis Apostolou, Sofia Mourati, Ioanna Vlachou, Maria Gougousi, and Ioannis Papasotiriou. 2021. "Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues" Molecules 26, no. 11: 3461. https://doi.org/10.3390/molecules26113461
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