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Open AccessFeature PaperArticle

Bivalent Metal-Chelating Properties of Harzianic Acid Produced by Trichoderma pleuroticola Associated to the Gastropod Melarhaphe neritoides

1
Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy
2
Council for Agricultural Research and Economics, Research Centre for Olive, Fruit and Citrus Crops, 81100 Caserta, Italy
3
Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy
4
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy
5
Institute for Sustainable Plant Protection, National Research Council, 80055 Portici, Italy
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(9), 2147; https://doi.org/10.3390/molecules25092147
Received: 14 April 2020 / Revised: 28 April 2020 / Accepted: 29 April 2020 / Published: 4 May 2020
(This article belongs to the Special Issue Natural Secondary Metabolites)
Harzianic acid is a secondary metabolite of Trichoderma, structurally belonging to the dienyltetramic acid subgroup of the tetramic acids. Biological activities of harzianic acid are of great interest for its antimicrobial and plant growth-promoting activities, which might be related to its chelating properties. In the present work harzianic acid, isolated from cultures of a strain of Trichoderma pleuroticola associated to the gastropod Melarhaphe neritoides, was studied as a complexant agent of a number of biologically relevant transition metals (i.e., Zn2+, Fe2+, Cu2+, and Mn2+), using UV-VIS, potentiometry, MS and NMR techniques. Our findings show the coordination capacity of harzianic acid toward the above cations through the formation of neutral or charged complexes in a variable ratio depending on the metal and pH conditions. View Full-Text
Keywords: Trichoderma secondary metabolites; bioactive products; chelating metal; tetramic acids; harzianic acid complexes Trichoderma secondary metabolites; bioactive products; chelating metal; tetramic acids; harzianic acid complexes
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De Tommaso, G.; Salvatore, M.M.; Nicoletti, R.; DellaGreca, M.; Vinale, F.; Bottiglieri, A.; Staropoli, A.; Salvatore, F.; Lorito, M.; Iuliano, M.; Andolfi, A. Bivalent Metal-Chelating Properties of Harzianic Acid Produced by Trichoderma pleuroticola Associated to the Gastropod Melarhaphe neritoides. Molecules 2020, 25, 2147.

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