Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthetic Procedure and Characterization
2.2. Crystal Structure
2.3. Antibacterial and Antifungal Properties
2.4. Antiviral Activity
2.5. Cytotoxic Properties on Normal and Cancer Cell Lines
3. Experimental
3.1. Materials and Methods
3.2. Antibacterial and Antifungal Activity Studies
3.3. Cell Cultures
3.4. Cytotoxicity Assay
3.5. Virucidal Activity According to PN-EN 14476
3.6. Antiviral Assay
3.7. Synthesis and Characterization of BioMOF 1
3.8. X-ray Crystallography
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the compound 1 are available from the authors. |
MIC [µg·mL−1] | Normalized MIC [nmol·mL−1] a | ||||
---|---|---|---|---|---|
Entry | Strains | 1 | AgNO3 b | 1 | AgNO3 b |
1 | P. aeruginosa | 5 | 9 | 14 | 53 |
2 | E. coli | 5 | 9 | 14 | 53 |
3 | S. aureus | 8 | 20 | 22 | 118 |
4 | C. albicans | 30 | 40 | 83 | 236 |
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Jaros, S.W.; Król, J.; Bażanów, B.; Poradowski, D.; Chrószcz, A.; Nesterov, D.S.; Kirillov, A.M.; Smoleński, P. Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid. Molecules 2020, 25, 2119. https://doi.org/10.3390/molecules25092119
Jaros SW, Król J, Bażanów B, Poradowski D, Chrószcz A, Nesterov DS, Kirillov AM, Smoleński P. Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid. Molecules. 2020; 25(9):2119. https://doi.org/10.3390/molecules25092119
Chicago/Turabian StyleJaros, Sabina W., Jarosław Król, Barbara Bażanów, Dominik Poradowski, Aleksander Chrószcz, Dmytro S. Nesterov, Alexander M. Kirillov, and Piotr Smoleński. 2020. "Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid" Molecules 25, no. 9: 2119. https://doi.org/10.3390/molecules25092119