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Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues

1
Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK
2
Medicinal Chemistry Knowledge Center, Stanford ChEM-H, 290 Jane Stanford Way, Stanford, CA 94305, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2020, 25(9), 2050; https://doi.org/10.3390/molecules25092050
Received: 2 April 2020 / Revised: 20 April 2020 / Accepted: 25 April 2020 / Published: 28 April 2020
(This article belongs to the Special Issue Advances in Anticancer Drug Discovery)
Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, these materials do have limitations and the development of next generation compounds remains a topic of significant interest and necessity. Herein, we discuss recent advances in the chemical synthesis and biological evaluation of nucleoside analogues as potential anticancer agents. Focus is paid to 4′-heteroatom substitution of the furanose oxygen, 2′-, 3′-, 4′- and 5′-position ring modifications and the development of new prodrug strategies for these materials. View Full-Text
Keywords: nucleoside analogue; anti-cancer; chemical synthesis; heteroatom replacement; chemotherapeutic; prodrug nucleoside analogue; anti-cancer; chemical synthesis; heteroatom replacement; chemotherapeutic; prodrug
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MDPI and ACS Style

Guinan, M.; Benckendorff, C.; Smith, M.; Miller, G.J. Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Molecules 2020, 25, 2050. https://doi.org/10.3390/molecules25092050

AMA Style

Guinan M, Benckendorff C, Smith M, Miller GJ. Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Molecules. 2020; 25(9):2050. https://doi.org/10.3390/molecules25092050

Chicago/Turabian Style

Guinan, Mieke; Benckendorff, Caecilie; Smith, Mark; Miller, Gavin J. 2020. "Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues" Molecules 25, no. 9: 2050. https://doi.org/10.3390/molecules25092050

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