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Open AccessArticle

Phytocomplex Characterization and Biological Evaluation of Powdered Fruits and Leaves from Elaeagnus angustifolia

1
Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
2
Department of Drug Chemistry and Technologies, “Sapienza” University of Rome, 00185 Rome, Italy
3
Department of Experimental Medicine, “Sapienza” University of Rome, 00185 Rome, Italy
4
Erciyes University Halil Bayraktar Health Services Vocational College, Kayseri 38039, Turkey
5
Ziya Eren Drug Application and Research Center, Erciyes University, Kayseri 38039, Turkey
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Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey
*
Authors to whom correspondence should be addressed.
Academic Editor: Ericsson Coy-Barrera
Molecules 2020, 25(9), 2021; https://doi.org/10.3390/molecules25092021
Received: 25 March 2020 / Revised: 16 April 2020 / Accepted: 22 April 2020 / Published: 26 April 2020
(This article belongs to the Special Issue Natural Product Pharmacology and Medicinal Chemistry II)
Fully ripe fruits and mature leaves of Elaeagnus angustifolia were harvested and analyzed by means of analytical and biological tests to better comprehend the chemical composition and therapeutic/nutraceutical potential of this plant. Fruits and leaves were dried and the obtained powders were analyzed to study their color character and (via headspace gas chromatography) describe the chemical profile. Subsequently, they were submitted to a chloroform–methanol extraction, to a hydroalcoholic extraction procedure assisted or not by microwaves, and to an extraction with supercritical CO2, assisted or not by ethanol as the co-solvent, to detect the polyphenolic and the volatile content. The resulting extracts were evaluated in terms of chlorophyll and carotenoid content, polyphenolic content, volatile fraction, total phenolic content, total flavonoid content, antioxidant activity, radical scavenging activity, and enzymatic inhibition activity. The results confirmed the correlation between the chemical composition and the high antioxidant potential of leaf extracts compared to the fruit extracts in terms of the phenolic and pigment content. A promising effect against tyrosinase emerged for all the extracts, suggesting a therapeutic/nutraceutical use for this plant. Conversely, the volatile content from both natural matrices was similar. View Full-Text
Keywords: Elaeagnus angustifolia; MW-assisted extraction; scCO2-assisted extraction; pigments; polyphenols; HS-GC/MS; HPLC-DAD; antioxidant activity; enzyme inhibition activity Elaeagnus angustifolia; MW-assisted extraction; scCO2-assisted extraction; pigments; polyphenols; HS-GC/MS; HPLC-DAD; antioxidant activity; enzyme inhibition activity
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MDPI and ACS Style

Carradori, S.; Cairone, F.; Garzoli, S.; Fabrizi, G.; Iazzetti, A.; Giusti, A.M.; Menghini, L.; Uysal, S.; Ak, G.; Zengin, G.; Cesa, S. Phytocomplex Characterization and Biological Evaluation of Powdered Fruits and Leaves from Elaeagnus angustifolia. Molecules 2020, 25, 2021.

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