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Open AccessArticle

Hematite Nanoparticles from Unexpected Reaction of Ferrihydrite with Concentrated Acids for Biomedical Applications

1
Moscow Institute of Physics and Technology, 9 Institutskiy per., Dolgoprudny, 141700 Moscow Region, Russia
2
Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia
3
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St., 16/10, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editors: Luigi Paduano and Giuseppe Vitiello
Molecules 2020, 25(8), 1984; https://doi.org/10.3390/molecules25081984
Received: 19 March 2020 / Revised: 17 April 2020 / Accepted: 20 April 2020 / Published: 23 April 2020
(This article belongs to the Special Issue Complex Multifunctional Organic/Inorganic Nanocarriers)
The development of synthetic ways to fabricate nanosized materials with a well-defined shape, narrow-sized distribution, and high stability is of great importance to a rapidly developing area of nanotechnology. Here, we report an unusual reaction between amorphous two-line ferrihydrite and concentrated sulfuric or other mineral and organic acids. Instead of the expected dissolution, we observed the formation of new narrow-distributed brick-red nanoparticles (NPs) of hematite. Different acids produce similar nanoparticles according to scanning (SEM) and transmission electron microscopy (TEM), selected area electron diffraction (SAED), X-ray diffraction (XRD), infrared spectroscopy (FTIR), and energy-dispersive X-ray spectroscopy (EDX). The reaction demonstrates new possibilities for the synthesis of acid-resistant iron oxide nanoparticles and shows a novel pathway for the reaction of iron hydroxide with concentrated acids. The biomedical potential of the fabricated nanoparticles is demonstrated by the functionalization of the particles with polymers, fluorescent labels, and antibodies. Three different applications are demonstrated: i) specific targeting of the red blood cells, e.g., for red blood cell (RBC)-hitchhiking; ii) cancer cell targeting in vitro; iii) infrared ex vivo bioimaging. This novel synthesis route may be useful for the development of iron oxide materials for such specificity-demanding applications such as nanosensors, imaging, and therapy. View Full-Text
Keywords: hematite nanoparticles; nanoparticle synthesis; ferrihydrite; polymer coating; bioconjugation; antibodies; red blood cells; HER2/neu; bioimaging; cancer cell targeting hematite nanoparticles; nanoparticle synthesis; ferrihydrite; polymer coating; bioconjugation; antibodies; red blood cells; HER2/neu; bioimaging; cancer cell targeting
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MDPI and ACS Style

Lunin, A.V.; Lizunova, A.A.; Mochalova, E.N.; Yakovtseva, M.N.; Cherkasov, V.R.; Nikitin, M.P.; Kolychev, E.L. Hematite Nanoparticles from Unexpected Reaction of Ferrihydrite with Concentrated Acids for Biomedical Applications. Molecules 2020, 25, 1984.

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