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Open AccessArticle

Separation of Biological Entities from Human Blood by Using Magnetic Nanocomposites Obtained from Zeolite Precursors

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Department of Applied Science and Technology and INSTM Unit of Torino-Politecnico, Corso Duca degli Abruzzi 24, Politecnico di Torino, 10129 Torino, Italy
2
Department of Civil and Mechanical Engineering and INSTM Research Unit, Università degli Studi di Cassino e del Lazio Meridionale, Via G. Di Biasio 43, 03043 Cassino, FR, Italy
3
PoliTO BioMED Interdepartmental LAB, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
4
Nurex srl, Z.I. Predda Niedda, 07100 Sassari, Italy
5
INRIM, Nanoscience and Materials Division, Strada delle Cacce 91, 10135 Torino, Italy
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(8), 1803; https://doi.org/10.3390/molecules25081803
Received: 27 March 2020 / Revised: 8 April 2020 / Accepted: 10 April 2020 / Published: 14 April 2020
(This article belongs to the Special Issue New Nanomaterials: Synthesis, Characterization and Applications)
In this work, three novel magnetic metal–ceramic nanocomposites were obtained by thermally treating Fe-exchanged zeolites (either A or X) under reducing atmosphere at relatively mild temperatures (750–800 °C). The so-obtained materials were thoroughly characterized from the point of view of their physico-chemical properties and, then, used as magnetic adsorbents in the separation of the target gene factors V and RNASE and of the Staphylococcus aureus bacteria DNA from human blood. Such results were compared with those obtained by using a top ranking commercial separation system (namely, SiMAG-N-DNA by Chemicell). The results obtained by using the novel magnetic adsorbents were similar to (or even better than) those obtained by using the commercial system, both during manual and automated separations, provided that a proper protocol was adopted. Particularly, the novel magnetic adsorbents showed high sensitivity during tests performed with small volumes of blood. Finally, the feasible production of such magnetic adsorbents by an industrial process was envisaged as well. View Full-Text
Keywords: biological separations; porous metal–ceramic nanocomposites; magnetic nanoparticles; zeolite precursor; thermal treatment; adsorption biological separations; porous metal–ceramic nanocomposites; magnetic nanoparticles; zeolite precursor; thermal treatment; adsorption
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MDPI and ACS Style

Esposito, S.; Marocco, A.; Dell’Agli, G.; Bonelli, B.; Mannu, F.; Allia, P.; Tiberto, P.; Barrera, G.; Pansini, M. Separation of Biological Entities from Human Blood by Using Magnetic Nanocomposites Obtained from Zeolite Precursors. Molecules 2020, 25, 1803.

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