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Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

Department of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia St, Bucharest 020956, Romania
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Academic Editors: Giuseppe Manfroni and Tommaso Felicetti
Molecules 2020, 25(6), 1347; https://doi.org/10.3390/molecules25061347
Received: 20 January 2020 / Revised: 1 March 2020 / Accepted: 12 March 2020 / Published: 16 March 2020
(This article belongs to the Special Issue Quinolones: Chemistry and Biological Activities)
Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability. An important feature of these molecules is their capacity to bind metal ions in complexes with relevant biological and analytical applications. Interestingly, lanthanide ions possess extremely attractive properties that result from the behavior of the internal 4f electrons, behavior which is not lost upon ionization, nor after coordination. Subsequently, a more detailed discussion about metal complexes of quinolones with lanthanide ions in terms of chemical and biological properties is made. These complexes present a series of characteristics, such as narrow and highly structured emission bands; large gaps between absorption and emission wavelengths (Stokes shifts); and long excited-state lifetimes, which render them suitable for highly sensitive and selective analytical methods of quantitation. Moreover, quinolones have been widely prescribed in both human and animal treatments, which has led to an increase in their impact on the environment, and therefore to a growing interest in the development of new methods for their quantitative determination. Therefore, analytical applications for the quantitative determination of quinolones, lanthanide and miscellaneous ions and nucleic acids, along with other applications, are reviewed here. View Full-Text
Keywords: fluoroquinolones; lanthanides; metal complexes; biological activity; quantitative determination fluoroquinolones; lanthanides; metal complexes; biological activity; quantitative determination
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MDPI and ACS Style

Măciucă, A.-M.; Munteanu, A.-C.; Uivarosi, V. Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity. Molecules 2020, 25, 1347. https://doi.org/10.3390/molecules25061347

AMA Style

Măciucă A-M, Munteanu A-C, Uivarosi V. Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity. Molecules. 2020; 25(6):1347. https://doi.org/10.3390/molecules25061347

Chicago/Turabian Style

Măciucă, Ana-Mădălina; Munteanu, Alexandra-Cristina; Uivarosi, Valentina. 2020. "Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity" Molecules 25, no. 6: 1347. https://doi.org/10.3390/molecules25061347

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