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An Overview of the Potential Antineoplastic Effects of Casticin

Department of Pharmacology—Biomedicine, The University of Melbourne, Parkville, VIC 3010, Australia
Department of Biochemistry, Quaid-i-Azam University, Higher Education Commission of Pakistan, Islamabad 44000, Pakistan
Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, #47, Kyungheedae-gil, Dongdaemoon-gu, Seoul 130–701, Korea
Authors to whom correspondence should be addressed.
Academic Editors: Simona Collina and Mariarosaria Miloso
Molecules 2020, 25(6), 1287;
Received: 10 February 2020 / Revised: 9 March 2020 / Accepted: 9 March 2020 / Published: 12 March 2020
(This article belongs to the Special Issue Recent Advances in Anticancer Drugs II)
Cancer persists as one of the leading causes of deaths worldwide, contributing to approximately 9.6 million deaths per annum in recent years. Despite the numerous advancements in cancer treatment, there is still abundant scope to mitigate recurrence, adverse side effects and toxicities caused by existing pharmaceutical drugs. To achieve this, many phytochemicals from plants and natural products have been tested against cancer cell lines in vivo and in vitro. Likewise, casticin, a flavonoid extracted from the Vitex species, has been isolated from the leaves and seeds of V. trifolia and V. agnus-castus. Casticin possesses a wide range of therapeutic properties, including analgesic, anti-inflammatory, antiangiogenic, antiasthmatic and antineoplastic activities. Several studies have been conducted on the anticancer effects of casticin against cancers, including breast, bladder, oral, lung, leukemia and hepatocellular carcinomas. The compound inhibits invasion, migration and proliferation and induces apoptosis (casticin-induced, ROS-mediated and mitochondrial-dependent) and cell cycle arrest (G0/G1, G2/M, etc.) through different signaling pathways, namely the PI3K/Akt, NF-κB, STAT3 and FOXO3a/FoxM1 pathways. This review summarizes the chemo-preventive ability of casticin as an antineoplastic agent against several malignancies. View Full-Text
Keywords: cancer; casticin; flavonoid; apoptosis; PI3K/Akt; NF-κB; STAT3; FOXO3a/FoxM1 cancer; casticin; flavonoid; apoptosis; PI3K/Akt; NF-κB; STAT3; FOXO3a/FoxM1
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MDPI and ACS Style

Ramchandani, S.; Naz, I.; Lee, J.H.; Khan, M.R.; Ahn, K.S. An Overview of the Potential Antineoplastic Effects of Casticin. Molecules 2020, 25, 1287.

AMA Style

Ramchandani S, Naz I, Lee JH, Khan MR, Ahn KS. An Overview of the Potential Antineoplastic Effects of Casticin. Molecules. 2020; 25(6):1287.

Chicago/Turabian Style

Ramchandani, Shanaya, Irum Naz, Jong H. Lee, Muhammad R. Khan, and Kwang S. Ahn. 2020. "An Overview of the Potential Antineoplastic Effects of Casticin" Molecules 25, no. 6: 1287.

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