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EPR Spectroscopy: A Powerful Tool to Analyze Supramolecular Host•Guest Complexes of Stable Radicals with Cucurbiturils
Review

Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils

Molecular Imaging, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany
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Molecules 2020, 25(4), 957; https://doi.org/10.3390/molecules25040957
Received: 27 January 2020 / Revised: 14 February 2020 / Accepted: 18 February 2020 / Published: 20 February 2020
(This article belongs to the Special Issue Characterization Techniques in Supramolecular Chemistry)
Cucurbit[n]urils (CB[n]s) are a family of macrocyclic host molecules that find various applications in drug delivery, molecular switching, and dye displacement assays. The CB[n]s with n = 5–7 have also been studied with 129Xe-NMR. They bind the noble gas with a large range of exchange rates. Starting with insights from conventional direct detection of bound Xe, this review summarizes recent achievements with chemical exchange saturation transfer (CEST) detection of efficiently exchanging Xe in various CB[n]-based supramolecular systems. Unprecedented sensitivity has been reached by combining the CEST method with hyperpolarized Xe, the production of which is also briefly described. Applications such as displacement assays for enzyme activity detection and rotaxanes as emerging types of Xe biosensors are likewise discussed in the context of biomedical applications and pinpoint future directions for translating this field to preclinical studies. View Full-Text
Keywords: cucurbit[n]uril; Xe-NMR; HyperCEST; displacement assays; supramolecular systems cucurbit[n]uril; Xe-NMR; HyperCEST; displacement assays; supramolecular systems
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MDPI and ACS Style

Jayapaul, J.; Schröder, L. Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils. Molecules 2020, 25, 957. https://doi.org/10.3390/molecules25040957

AMA Style

Jayapaul J, Schröder L. Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils. Molecules. 2020; 25(4):957. https://doi.org/10.3390/molecules25040957

Chicago/Turabian Style

Jayapaul, Jabadurai, and Leif Schröder. 2020. "Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils" Molecules 25, no. 4: 957. https://doi.org/10.3390/molecules25040957

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