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Applications of Bolm’s Ligand in Enantioselective Synthesis

Department of Organic Chemistry, Faculty of Science, Charles University, Albertov 6, 128 43 Praha 2, Czech Republic
Author to whom correspondence should be addressed.
Molecules 2020, 25(4), 958;
Received: 3 February 2020 / Revised: 17 February 2020 / Accepted: 17 February 2020 / Published: 20 February 2020
(This article belongs to the Special Issue Bipyridines: Synthesis, Functionalization and Applications)
One pathway for the preparation of enantiomerically pure compounds from prochiral substrates is the use of metal complex catalysis with chiral ligands. Compared to the other frequently used chiral ligands, chiral 2,2’-bipyridines have been underexploited, despite the data indicating that such ligands have considerable potential in synthetic chemistry. One of those is the so-called Bolm’s ligand, a compound possessing chiral alcohol moieties in the side chains attached to the 2,2’-bipyridine scaffold. Various metal salts have been used in combination with Bolm’s ligand as potent catalysts able to bring about enantioselective alkylations, allylations, conjugate additions, desymmetrization of meso-epoxides, aldol reactions, etc. This review aims to summarize Bolm’s ligand applications in the area of enantioselective synthesis over the last three decades since its preparation. View Full-Text
Keywords: catalysis; enantioselectivity; synthesis; bipyridine catalysis; enantioselectivity; synthesis; bipyridine
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MDPI and ACS Style

Bednářová, E.; Malatinec, Š.; Kotora, M. Applications of Bolm’s Ligand in Enantioselective Synthesis. Molecules 2020, 25, 958.

AMA Style

Bednářová E, Malatinec Š, Kotora M. Applications of Bolm’s Ligand in Enantioselective Synthesis. Molecules. 2020; 25(4):958.

Chicago/Turabian Style

Bednářová, Eva, Štefan Malatinec, and Martin Kotora. 2020. "Applications of Bolm’s Ligand in Enantioselective Synthesis" Molecules 25, no. 4: 958.

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