Next Article in Journal
CRANAD-28: A Robust Fluorescent Compound for Visualization of Amyloid Beta Plaques
Previous Article in Journal
Copper Complexing Capacity and Trace Metal Content in Common and Balsamic Vinegars: Impact of Organic Matter
Previous Article in Special Issue
Redox-Active Monolayers Self-Assembled on Gold Electrodes—Effect of Their Structures on Electrochemical Parameters and DNA Sensing Ability
Open AccessFeature PaperArticle

Supramolecular and Liquid Crystalline Contributions to the Assembly of Myofibril

Chemistry Department, Duke University, Durham, NC 27708, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Laura Rodríguez
Molecules 2020, 25(4), 862; https://doi.org/10.3390/molecules25040862 (registering DOI)
Received: 3 January 2020 / Revised: 6 February 2020 / Accepted: 12 February 2020 / Published: 15 February 2020
(This article belongs to the Special Issue Advances in Supramolecular Chemistry)
We compare steps observed during the fibrillogenesis of myofibrils with the sequence of steps predictable by a recent analysis of the structurization and functioning of striated muscles. The predicted assembly steps are based solely on fundamental equilibrium processes, particularly supramolecular interactions and liquid crystalline alignment of the rigid thick and thin filaments hosted within the sarcomer. Satisfactory agreement is obtained between several of the observed and the predicted fibrillogenesis steps. In several cases, however, the actual steps appear to be more complex than expected, evidencing the occurrence of transport and kinetic pathways that may assist the attainment of the equilibrium structure. The memory of the order of a precursor mesophase is imprinted during the remodeling of the surfaces at which the two sets of filaments are anchored. The relevance of the present analysis to the functioning of the myofibril is considered. View Full-Text
Keywords: myofibrillogenesis; chemical recognition; shape recognition; supramolecular polymerization; liquid crystallinity myofibrillogenesis; chemical recognition; shape recognition; supramolecular polymerization; liquid crystallinity
Show Figures

Graphical abstract

MDPI and ACS Style

Ciferri, A.; Crumbliss, A.L. Supramolecular and Liquid Crystalline Contributions to the Assembly of Myofibril. Molecules 2020, 25, 862.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop