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Ferritin Nanocages for Protein Delivery to Tumor Cells

Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
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Molecules 2020, 25(4), 825; https://doi.org/10.3390/molecules25040825 (registering DOI)
Received: 17 January 2020 / Revised: 11 February 2020 / Accepted: 13 February 2020 / Published: 13 February 2020
The delivery of therapeutic proteins is one of the greatest challenges in the treatment of human diseases. In this frame, ferritins occupy a very special place. Thanks to their hollow spherical structure, they are used as modular nanocages for the delivery of anticancer drugs. More recently, the possibility of encapsulating even small proteins with enzymatic or cytotoxic activity is emerging. Among all ferritins, particular interest is paid to the Archaeoglobus fulgidus one, due to its peculiar ability to associate/dissociate in physiological conditions. This protein has also been engineered to allow recognition of human receptors and used in vitro for the delivery of cytotoxic proteins with extremely promising results. View Full-Text
Keywords: ferritin; drug delivery; therapeutic proteins; nanocarrier; Archaeoglobus fulgidus; TfR1 receptor; tumor cells ferritin; drug delivery; therapeutic proteins; nanocarrier; Archaeoglobus fulgidus; TfR1 receptor; tumor cells
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Palombarini, F.; Di Fabio, E.; Boffi, A.; Macone, A.; Bonamore, A. Ferritin Nanocages for Protein Delivery to Tumor Cells. Molecules 2020, 25, 825.

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