Next Article in Journal
Targeting Tumors Using Peptides
Next Article in Special Issue
Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
Previous Article in Journal
1H NMR Metabolic Profile of Scyphomedusa Rhizostoma pulmo (Scyphozoa, Cnidaria) in Female Gonads and Somatic Tissues: Preliminary Results
Previous Article in Special Issue
The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro
Open AccessFeature PaperArticle

New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Departamento de Química Orgánica y Química Inorgánica, IQAR, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
Ramón y Cajal Health Research Institute (IRYCIS), IRYCIS, 28034 Madrid, Spain
Departamento de Química Analítica, Química Física e Ingeniería Química, IQAR, Universidad de Alcalá Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(4), 807; (registering DOI)
Received: 14 January 2020 / Revised: 6 February 2020 / Accepted: 10 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Dendrimers in Biomedicine)
The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of 19F magnetic resonance imaging (19F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by 19F-MRI. View Full-Text
Keywords: carbosilane; dendrimer; fluorine; micelle carbosilane; dendrimer; fluorine; micelle
Show Figures

Figure 1

MDPI and ACS Style

Mencia, G.; Lozano-Cruz, T.; Valiente, M.; de la Mata, J.; Cano, J.; Gómez, R. New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton. Molecules 2020, 25, 807.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop