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Open AccessFeature PaperArticle

New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

1
Departamento de Química Orgánica y Química Inorgánica, IQAR, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
2
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
3
Ramón y Cajal Health Research Institute (IRYCIS), IRYCIS, 28034 Madrid, Spain
4
Departamento de Química Analítica, Química Física e Ingeniería Química, IQAR, Universidad de Alcalá Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(4), 807; https://doi.org/10.3390/molecules25040807 (registering DOI)
Received: 14 January 2020 / Revised: 6 February 2020 / Accepted: 10 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Dendrimers in Biomedicine)
The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of 19F magnetic resonance imaging (19F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by 19F-MRI. View Full-Text
Keywords: carbosilane; dendrimer; fluorine; micelle carbosilane; dendrimer; fluorine; micelle
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MDPI and ACS Style

Mencia, G.; Lozano-Cruz, T.; Valiente, M.; de la Mata, J.; Cano, J.; Gómez, R. New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton. Molecules 2020, 25, 807.

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