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Open AccessArticle

Components of Volatile Fractions from Eucalyptus camaldulensis Leaves from Iraqi–Kurdistan and Their Potent Spasmolytic Effects

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Biology Department, Faculty of Science, University of Zakho, Duhok 42001, Kurdistan Region, Iraq
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Department of Chemistry, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy
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Department of Biology, College of Science, International University of Erbil, Erbil 44001, Kurdistan Region, Iraq
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Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja, San Cayetano Alto s/n, Loja 1101608, Ecuador
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Medical Analysis Department, Faculty of Science, Tishk International University, Erbil 44001, Kurdistan Region, Iraq
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Authors to whom correspondence should be addressed.
Academic Editor: Michiho Ito
Molecules 2020, 25(4), 804; https://doi.org/10.3390/molecules25040804 (registering DOI)
Received: 30 December 2019 / Revised: 6 February 2020 / Accepted: 6 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Fragrant molecules with pharmacological activities)
Inhalation of vapors from a hot tea of Eucalyptus camaldulensis Dehnh. leaves is considered by Iraqi–Kurdistan people an effective spasmolytic and antipyretic remedy for the treatment of respiratory diseases. The constituents of volatile fractions isolated by hydrodistillation from dried leaves of the plant collected in Kurdistan were determined by GC-FID and GC-MS analyses. More than 90% components were identified. The most abundant constituents were 1,8-cineole, p-cymene, α-pinene, terpinen-4-ol, aromadendrene, and α-terpineol. The different volatile fractions induced relaxation on rat isolated aortic and tracheal rings in concentration-dependent manner. These effects appeared to be due to a complex interaction between various terpenoid components rather than being only due to the main oil constituent, 1,8-cineole. The KCa channel and the NO pathway were not significantly involved in the relaxation mechanism, while Ca2+ channels played a major role in the spasmolytic effects. View Full-Text
Keywords: Eucalyptus camaldulensis; Myrtaceae; volatile fractions; Kurdistan traditional medicine; relaxant effects on rat contracted aorta and tracheal rings; calcium channels Eucalyptus camaldulensis; Myrtaceae; volatile fractions; Kurdistan traditional medicine; relaxant effects on rat contracted aorta and tracheal rings; calcium channels
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Kheder, D.A.; Al-Habib, O.A.M.; Gilardoni, G.; Vidari, G. Components of Volatile Fractions from Eucalyptus camaldulensis Leaves from Iraqi–Kurdistan and Their Potent Spasmolytic Effects. Molecules 2020, 25, 804.

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