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Article

Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia

1
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, Avenue de l’Observatoire, 75006 Paris, France
2
Laboratoires Clarins, 5 Rue Ampère, 95300 Pontoise, France
3
Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland
4
Muséum National d’Histoire Naturelle, Unité Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245, CP 54, 57 rue Cuvier, 75005 Paris, France
5
Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens (LEEISA), USR 3456, Université De Guyane, CNRS Guyane, 275 Route de Montabo, 97334 Cayenne, French Guiana
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(3), 589; https://doi.org/10.3390/molecules25030589
Received: 13 December 2019 / Revised: 23 January 2020 / Accepted: 26 January 2020 / Published: 29 January 2020
(This article belongs to the Special Issue Terpenes and Terpene Derivatives)
This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity. View Full-Text
Keywords: Sideritis hyssopifolia; ent-kaurane; anti-inflammatory; NMR Sideritis hyssopifolia; ent-kaurane; anti-inflammatory; NMR
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MDPI and ACS Style

Aimond, A.; Calabro, K.; Audoin, C.; Olivier, E.; Dutot, M.; Buron, P.; Rat, P.; Laprévote, O.; Prado, S.; Roulland, E.; Thomas, O.P.; Genta-Jouve, G. Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia. Molecules 2020, 25, 589. https://doi.org/10.3390/molecules25030589

AMA Style

Aimond A, Calabro K, Audoin C, Olivier E, Dutot M, Buron P, Rat P, Laprévote O, Prado S, Roulland E, Thomas OP, Genta-Jouve G. Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia. Molecules. 2020; 25(3):589. https://doi.org/10.3390/molecules25030589

Chicago/Turabian Style

Aimond, Axelle, Kevin Calabro, Coralie Audoin, Elodie Olivier, Mélody Dutot, Pauline Buron, Patrice Rat, Olivier Laprévote, Soizic Prado, Emmanuel Roulland, Olivier P. Thomas, and Grégory Genta-Jouve. 2020. "Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia" Molecules 25, no. 3: 589. https://doi.org/10.3390/molecules25030589

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