Next Article in Journal
Tannins of Conifer Bark as Nordic Piquancy—Sustainable Preservative and Aroma?
Previous Article in Journal
Approaches to PET Imaging of Glioblastoma
Open AccessArticle

Utilization of Nutmeg (Myristica fragrans Houtt.) Seed Hydrodistillation Time to Produce Essential Oil Fractions with Varied Compositions and Pharmacological Effects

1
National Center for Natural Product Research, University of Mississippi, Oxford, MS 38677, USA
2
U.S. Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, Oxford, MS 38677, USA
3
Central Oregon Agriculture Research and Extension Center, Oregon State University, 850 NW Dogwood Ln, Madras, OR 97741, USA
4
Faculty of Agriculture, Dalhousie University, PO Box 550, Truro, NS B2N 5E3, Canada
5
Crop and Soil Science Department, Oregon State University, 3050 SW Campus Way, 109 Crop Science Building, Corvallis, OR 97331, USA
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(3), 565; https://doi.org/10.3390/molecules25030565
Received: 14 December 2019 / Revised: 19 January 2020 / Accepted: 26 January 2020 / Published: 28 January 2020
The intent of this study was to utilize distillation timeframes (DT) of nutmeg (Myristica fragrans) essential oil (EO) to generate fractions with differential chemical compositions and bioactivity. Ten fractions were captured at the following distillation timeframes: 0.0–0.5, 0.5–1.0, 1.0–2.5, 2.5–5.0, 5.0–10, 10–30, 30–60, 60–90, 90–120, and 120–240 min. In addition, a control EO was collected from a straight 0–240 min non-stop distillation. ANOVA and advanced regression modeling revealed that the produced EO fractions possess substantial variation in the concentration of potentially desired compounds. The concentrations (%) of α-phellandrene, 3-carene, p-cymene, limonene, α-thujene, α-pinene, camphene, sabinene, β-pinene, and myrcene decreased, while the concentrations (%) of α-terpinene, γ-terpinene, terpinolene, and myristicin increased in later DT fractions. Nutmeg EO showed some antimalarial activity against Plasmodium falciparum D6, but did not exhibit significant antifungal activity. In general, nutmeg seed oil yields increased with an increase of DT. These results may be utilized by industries using nutmeg EO. View Full-Text
Keywords: Regression models; α-phellandrene; 3-carene; p-cymene; limonene; α-thujene; α-pinene; camphene; sabinene; β-pinene; myrcene; α-terpinene; γ-terpinene; terpinolene; myristicin Regression models; α-phellandrene; 3-carene; p-cymene; limonene; α-thujene; α-pinene; camphene; sabinene; β-pinene; myrcene; α-terpinene; γ-terpinene; terpinolene; myristicin
Show Figures

Figure 1

MDPI and ACS Style

Ibrahim, M.A.; Cantrell, C.L.; Jeliazkova, E.A.; Astatkie, T.; Zheljazkov, V.D. Utilization of Nutmeg (Myristica fragrans Houtt.) Seed Hydrodistillation Time to Produce Essential Oil Fractions with Varied Compositions and Pharmacological Effects. Molecules 2020, 25, 565.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop