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Article

Design, Preparation, and Evaluation of a Novel 99mTcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent

Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
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Author to whom correspondence should be addressed.
Academic Editor: Rodica Olar
Molecules 2020, 25(24), 5837; https://doi.org/10.3390/molecules25245837
Received: 31 October 2020 / Revised: 6 December 2020 / Accepted: 7 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue New Trends in Developing Complexes as Biological Active Species)
In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [99mTcN]2+ core to obtain the 99mTcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria binding assay indicated that 99mTcN-CPF2XT had specificity to bacteria. A study of biodistribution in mice showed that 99mTcN-CPF2XT had a higher uptake in bacterial infection tissues than in turpentine-induced abscesses, indicating that it could distinguish bacterial infection from sterile inflammation. Compared to 99mTcN-CPFXDTC, the abscess/blood and abscess/muscle ratios of 99mTcN-CPF2XT were higher and the uptakes of 99mTcN-CPF2XT in the liver and lung were obviously decreased. The results suggested that 99mTcN-CPF2XT would be a potential bacterial infection imaging agent. View Full-Text
Keywords: ciprofloxacin xanthate; quinolones; infection imaging; 99mTc-radiolabeling ciprofloxacin xanthate; quinolones; infection imaging; 99mTc-radiolabeling
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MDPI and ACS Style

Fang, S.; Jiang, Y.; Gan, Q.; Ruan, Q.; Xiao, D.; Zhang, J. Design, Preparation, and Evaluation of a Novel 99mTcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent. Molecules 2020, 25, 5837. https://doi.org/10.3390/molecules25245837

AMA Style

Fang S, Jiang Y, Gan Q, Ruan Q, Xiao D, Zhang J. Design, Preparation, and Evaluation of a Novel 99mTcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent. Molecules. 2020; 25(24):5837. https://doi.org/10.3390/molecules25245837

Chicago/Turabian Style

Fang, Si’an, Yuhao Jiang, Qianqian Gan, Qing Ruan, Di Xiao, and Junbo Zhang. 2020. "Design, Preparation, and Evaluation of a Novel 99mTcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent" Molecules 25, no. 24: 5837. https://doi.org/10.3390/molecules25245837

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