Next Article in Journal
Optimization of Nazarov Cyclization of 2,4-Dimethyl-1,5-diphenylpenta-1,4-dien-3-one in Deep Eutectic Solvents by a Design of Experiments Approach
Next Article in Special Issue
Suppressive Effect of Two Cucurbitane-Type Triterpenoids from Momordica charantia on Cutibacterium acnes-Induced Inflammatory Responses in Human THP-1 Monocytic Cell and Mouse Models
Previous Article in Journal
Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis
Previous Article in Special Issue
Oxidative Stress Biomarkers and Peripheral Endothelial Dysfunction in Rheumatoid Arthritis: A Monocentric Cross-Sectional Case-Control Study

The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients

Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
Unit of Respiratory Diseases, University Hospital Sassari (AOU), 07100 Sassari, Italy
Pneumology Unit, Santissima Trinità Hospital, 09121 Cagliari, Italy
Mater Olbia Hospital, 07026 Olbia, Italy
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
Operative Unit of Hematology, Center for Stem Cell Transplantation, San Francesco Hospital, 08100 Nuoro, Italy
Respiratory Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, University of Milan, 20122 Milan, Italy
Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide 5042, Australia
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Molecules 2020, 25(23), 5725;
Received: 18 November 2020 / Revised: 30 November 2020 / Accepted: 1 December 2020 / Published: 4 December 2020
(This article belongs to the Special Issue Anti-inflammatory and Anti-allergy Agents in Medicinal Chemistry-III)
Background. The rapid onset of a systemic pro-inflammatory state followed by acute respiratory distress syndrome is the leading cause of mortality in patients with COVID-19. We performed a retrospective observational study to explore the capacity of different complete blood cell count (CBC)-derived inflammation indexes to predict in-hospital mortality in this group. Methods. The neutrophil to lymphocyte ratio (NLR), derived NLR (dNLR), platelet to lymphocyte ratio (PLR), mean platelet volume to platelet ratio (MPR), neutrophil to lymphocyte × platelet ratio (NLPR), monocyte to lymphocyte ratio (MLR), systemic inflammation response index (SIRI), systemic inflammation index (SII), and the aggregate index of systemic inflammation (AISI) were calculated on hospital admission in 119 patients with laboratory confirmed COVID-19. Results. Non-survivors had significantly higher AISI, dNLR, NLPR, NLR, SII, and SIRI values when compared to survivors. Similarly, Kaplan–Meier survival curves showed significantly lower survival in patients with higher AISI, dNLR, MLR, NLPR, NLR, SII, and SIRI. However, after adjusting for confounders, only the SII remained significantly associated with survival (HR = 1.0001; 95% CI, 1.0000–1.0001, p = 0.029) in multivariate Cox regression analysis. Conclusions. The SII on admission independently predicts in-hospital mortality in COVID-19 patients and may assist with early risk stratification in this group. View Full-Text
Keywords: CBC; coronavirus; COVID-19; inflammation; SII CBC; coronavirus; COVID-19; inflammation; SII
Show Figures

Figure 1

MDPI and ACS Style

Fois, A.G.; Paliogiannis, P.; Scano, V.; Cau, S.; Babudieri, S.; Perra, R.; Ruzzittu, G.; Zinellu, E.; Pirina, P.; Carru, C.; Arru, L.B.; Fancellu, A.; Mondoni, M.; Mangoni, A.A.; Zinellu, A. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients. Molecules 2020, 25, 5725.

AMA Style

Fois AG, Paliogiannis P, Scano V, Cau S, Babudieri S, Perra R, Ruzzittu G, Zinellu E, Pirina P, Carru C, Arru LB, Fancellu A, Mondoni M, Mangoni AA, Zinellu A. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients. Molecules. 2020; 25(23):5725.

Chicago/Turabian Style

Fois, Alessandro G., Panagiotis Paliogiannis, Valentina Scano, Stefania Cau, Sergio Babudieri, Roberto Perra, Giulia Ruzzittu, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Luigi B. Arru, Alessandro Fancellu, Michele Mondoni, Arduino A. Mangoni, and Angelo Zinellu. 2020. "The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients" Molecules 25, no. 23: 5725.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop