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Open AccessArticle

Alkaloids: Therapeutic Potential against Human Coronaviruses

1
Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, University of the Western Cape, Bellville 7535, South Africa
2
Department of Pharmaceutical Sciences, Federal University of Paraíba, Paraíba 58051-900, Brazil
3
Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo 12311, Egypt
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Maria José U. Ferreira
Molecules 2020, 25(23), 5496; https://doi.org/10.3390/molecules25235496
Received: 30 September 2020 / Revised: 4 November 2020 / Accepted: 10 November 2020 / Published: 24 November 2020
(This article belongs to the Special Issue Alkaloids in Future Drug Discovery)
Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential use as bioactive agents against SARS-CoV-2. View Full-Text
Keywords: COVID-19; natural products; antiviral drug; SARS-CoV; MERS-CoV; coronaviruses; virus; SARS-CoV-2 COVID-19; natural products; antiviral drug; SARS-CoV; MERS-CoV; coronaviruses; virus; SARS-CoV-2
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MDPI and ACS Style

Fielding, B.C.; da Silva Maia Bezerra Filho, C.; Ismail, N.S.M.; Sousa, D.P.d. Alkaloids: Therapeutic Potential against Human Coronaviruses. Molecules 2020, 25, 5496. https://doi.org/10.3390/molecules25235496

AMA Style

Fielding BC, da Silva Maia Bezerra Filho C, Ismail NSM, Sousa DPd. Alkaloids: Therapeutic Potential against Human Coronaviruses. Molecules. 2020; 25(23):5496. https://doi.org/10.3390/molecules25235496

Chicago/Turabian Style

Fielding, Burtram C.; da Silva Maia Bezerra Filho, Carlos; Ismail, Nasser S.M.; Sousa, Damião P.d. 2020. "Alkaloids: Therapeutic Potential against Human Coronaviruses" Molecules 25, no. 23: 5496. https://doi.org/10.3390/molecules25235496

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