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Open AccessArticle

Alkaloids: Therapeutic Potential against Human Coronaviruses

Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, University of the Western Cape, Bellville 7535, South Africa
Department of Pharmaceutical Sciences, Federal University of Paraíba, Paraíba 58051-900, Brazil
Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo 12311, Egypt
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Maria José U. Ferreira
Molecules 2020, 25(23), 5496;
Received: 30 September 2020 / Revised: 4 November 2020 / Accepted: 10 November 2020 / Published: 24 November 2020
(This article belongs to the Special Issue Alkaloids in Future Drug Discovery)
Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential use as bioactive agents against SARS-CoV-2. View Full-Text
Keywords: COVID-19; natural products; antiviral drug; SARS-CoV; MERS-CoV; coronaviruses; virus; SARS-CoV-2 COVID-19; natural products; antiviral drug; SARS-CoV; MERS-CoV; coronaviruses; virus; SARS-CoV-2
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MDPI and ACS Style

Fielding, B.C.; da Silva Maia Bezerra Filho, C.; Ismail, N.S.M.; Sousa, D.P.d. Alkaloids: Therapeutic Potential against Human Coronaviruses. Molecules 2020, 25, 5496.

AMA Style

Fielding BC, da Silva Maia Bezerra Filho C, Ismail NSM, Sousa DPd. Alkaloids: Therapeutic Potential against Human Coronaviruses. Molecules. 2020; 25(23):5496.

Chicago/Turabian Style

Fielding, Burtram C.; da Silva Maia Bezerra Filho, Carlos; Ismail, Nasser S.M.; Sousa, Damião P.d. 2020. "Alkaloids: Therapeutic Potential against Human Coronaviruses" Molecules 25, no. 23: 5496.

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