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Article

Effect of Vitamin B Complex Treatment on Macrophages to Schwann Cells Association during Neuroinflammation after Peripheral Nerve Injury

1
Institute of Physiology and Biochemistry “Ivan Djaja”, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia
2
Institute for Orthopedic Surgery “Banjica”, 11000 Belgrade, Serbia
3
Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia
4
Department of Neurobiology, Institute for Biological Research “Sinisa Stankovic”, National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this study.
Academic Editors: Sokcheon Pak and Soo Liang Ooi
Molecules 2020, 25(22), 5426; https://doi.org/10.3390/molecules25225426
Received: 17 September 2020 / Revised: 5 November 2020 / Accepted: 6 November 2020 / Published: 19 November 2020
(This article belongs to the Special Issue Nutraceuticals in Immune Function)
Peripheral nerve injury (PNI) triggers a complex multi-cellular response involving the injured neurons, Schwann cells (SCs), and immune cells, often resulting in poor functional recovery. The aim of this study was to investigate the effects of the treatment with vitamin B (B1, B2, B3, B5, B6, and B12) complex on the interaction between macrophages and SCs during the recovery period after PNI. Transection of the motor branch of the femoral nerve followed by reconstruction by termino-terminal anastomosis was used as an experimental model. Isolated nerves from the sham (S), operated (O), and operated groups treated with the B vitamins (OT group) were used for immunofluorescence analysis. The obtained data indicated that PNI modulates interactions between macrophages and SCs in a time-dependent manner. The treatment with B vitamins complex promoted the M1-to M2-macrophage polarization and accelerated the transition from the non-myelin to myelin-forming SCs, an indicative of SCs maturation. The effect of B vitamins complex on both cell types was accompanied with an increase in macrophage/SC interactions, all of which correlated with the regeneration of the injured nerve. Clearly, the capacity of B vitamins to modulate macrophages-SCs interaction may be promising for the treatment of PNI. View Full-Text
Keywords: peripheral nerve injury; vitamin B complex; neuroinflammation; macrophages; Schwann cells peripheral nerve injury; vitamin B complex; neuroinflammation; macrophages; Schwann cells
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MDPI and ACS Style

Ehmedah, A.; Nedeljkovic, P.; Dacic, S.; Repac, J.; Draskovic-Pavlovic, B.; Vučević, D.; Pekovic, S.; Nedeljkovic, B.B. Effect of Vitamin B Complex Treatment on Macrophages to Schwann Cells Association during Neuroinflammation after Peripheral Nerve Injury. Molecules 2020, 25, 5426. https://doi.org/10.3390/molecules25225426

AMA Style

Ehmedah A, Nedeljkovic P, Dacic S, Repac J, Draskovic-Pavlovic B, Vučević D, Pekovic S, Nedeljkovic BB. Effect of Vitamin B Complex Treatment on Macrophages to Schwann Cells Association during Neuroinflammation after Peripheral Nerve Injury. Molecules. 2020; 25(22):5426. https://doi.org/10.3390/molecules25225426

Chicago/Turabian Style

Ehmedah, Adil, Predrag Nedeljkovic, Sanja Dacic, Jelena Repac, Biljana Draskovic-Pavlovic, Dragana Vučević, Sanja Pekovic, and Biljana B. Nedeljkovic. 2020. "Effect of Vitamin B Complex Treatment on Macrophages to Schwann Cells Association during Neuroinflammation after Peripheral Nerve Injury" Molecules 25, no. 22: 5426. https://doi.org/10.3390/molecules25225426

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