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Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components

1
School of Chemical Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea
2
School of Materials Science and Engineering, Nanyang Technological University, Singapore 637553, Singapore
3
Omni Colab Corporation, Suwon 16229, Korea
4
Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(22), 5414; https://doi.org/10.3390/molecules25225414
Received: 11 September 2020 / Revised: 11 November 2020 / Accepted: 16 November 2020 / Published: 19 November 2020
Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. An introduction to the composition and medicinal activities of BJO and its molecular components, including quassinoids and fatty acids, is first provided. Application examples involving each type of drug delivery vehicle are then critically presented. Future opportunities for nanomedicine delivery strategies in the field are also discussed and considered within the context of translational medicine needs and drug development processes. View Full-Text
Keywords: Brucea javanica oil; quassinoid; medicinal activity; nanomedicine; emulsion; liposome; spongosome; drug delivery Brucea javanica oil; quassinoid; medicinal activity; nanomedicine; emulsion; liposome; spongosome; drug delivery
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MDPI and ACS Style

Yoon, B.K.; Lim, Z.Y.; Jeon, W.-Y.; Cho, N.-J.; Kim, J.H.; Jackman, J.A. Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components. Molecules 2020, 25, 5414. https://doi.org/10.3390/molecules25225414

AMA Style

Yoon BK, Lim ZY, Jeon W-Y, Cho N-J, Kim JH, Jackman JA. Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components. Molecules. 2020; 25(22):5414. https://doi.org/10.3390/molecules25225414

Chicago/Turabian Style

Yoon, Bo K.; Lim, Zheng Y.; Jeon, Won-Yong; Cho, Nam-Joon; Kim, Jeong H.; Jackman, Joshua A. 2020. "Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components" Molecules 25, no. 22: 5414. https://doi.org/10.3390/molecules25225414

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