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Article

In Vivo Effect of Resveratrol-Loaded Solid Lipid Nanoparticles to Relieve Physical Fatigue for Sports Nutrition Supplements

by
Lili Qin
1,†,
Tianfeng Lu
1,†,
Yao Qin
1,
Yiwei He
1,
Ningxin Cui
1,
Ai Du
2 and
Jingyu Sun
1,*
1
Sports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China
2
School of Physics Science and Engineering, Tongji University, Shanghai 200092, China
*
Author to whom correspondence should be addressed.
†
Both authors contributed equally to this article.
Molecules 2020, 25(22), 5302; https://doi.org/10.3390/molecules25225302
Submission received: 25 October 2020 / Revised: 11 November 2020 / Accepted: 12 November 2020 / Published: 13 November 2020
(This article belongs to the Special Issue Preparation, Characterization, and Effect of Lipid Nanoparticles Used in Different Application Fields)
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Abstract

Resveratrol (RSV) is a natural flavonoid polyphenol compound extracted from the plants which shows various biological activities. However, the clinical application of RSV is limited by its poor aqueous solubility, rapid metabolism and poor bioavailability. In this study, resveratrol-loaded solid lipid nanoparticles (RSV- SLNs) was design as a nano-antioxidant against the physical fatigue. The resultant RSV-SLNs were characterized by photon correlation spectroscopy (PCS), transmission electron micrographs (TEM), zeta potential, differential scanning calorimetry (DSC) and Raman spectroscopy pattern. Furthermore, the in vivo anti-fatigue effect assays showed that RSV-SLNs prolonged the mice exhausted time and running distance. The biochemical parameters of blood related to fatigue suggested that RSV-SLNs have potential applications to improve the antioxidant defense of the mice after extensive exercise and confer anti-fatigue capability. Furthermore, the molecular mechanisms of antioxidant by RSV-SLNs supplementation was investigated through the analysis of silent information regulator 2 homolog 1 (SIRT1) protein expression, which demonstrated that it could downregulate the expression of SIRT1 and increase autophagy markers, microtubule-associated protein 1 light chain 3-II (LC3-II) and sequestosome-1 (SQSTM1/p62). These results reveal that the RSV-SLNs may have great potential used as a novel anti-fatigue sports nutritional supplement.
Keywords: solid lipid nanoparticles (SLNs); resveratrol; drug delivery; anti-fatigue; nutrition supplements solid lipid nanoparticles (SLNs); resveratrol; drug delivery; anti-fatigue; nutrition supplements

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MDPI and ACS Style

Qin, L.; Lu, T.; Qin, Y.; He, Y.; Cui, N.; Du, A.; Sun, J. In Vivo Effect of Resveratrol-Loaded Solid Lipid Nanoparticles to Relieve Physical Fatigue for Sports Nutrition Supplements. Molecules 2020, 25, 5302. https://doi.org/10.3390/molecules25225302

AMA Style

Qin L, Lu T, Qin Y, He Y, Cui N, Du A, Sun J. In Vivo Effect of Resveratrol-Loaded Solid Lipid Nanoparticles to Relieve Physical Fatigue for Sports Nutrition Supplements. Molecules. 2020; 25(22):5302. https://doi.org/10.3390/molecules25225302

Chicago/Turabian Style

Qin, Lili, Tianfeng Lu, Yao Qin, Yiwei He, Ningxin Cui, Ai Du, and Jingyu Sun. 2020. "In Vivo Effect of Resveratrol-Loaded Solid Lipid Nanoparticles to Relieve Physical Fatigue for Sports Nutrition Supplements" Molecules 25, no. 22: 5302. https://doi.org/10.3390/molecules25225302

APA Style

Qin, L., Lu, T., Qin, Y., He, Y., Cui, N., Du, A., & Sun, J. (2020). In Vivo Effect of Resveratrol-Loaded Solid Lipid Nanoparticles to Relieve Physical Fatigue for Sports Nutrition Supplements. Molecules, 25(22), 5302. https://doi.org/10.3390/molecules25225302

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