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Article

New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity

1
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
2
Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
3
Scientific and Technological Research Equipment Centre, Chulalongkorn University, Bangkok 10330, Thailand
4
Natural Products for Ageing and Chronic Diseases Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Yasuyoshi Miyata
Molecules 2020, 25(21), 4931; https://doi.org/10.3390/molecules25214931
Received: 30 September 2020 / Revised: 11 October 2020 / Accepted: 22 October 2020 / Published: 25 October 2020
(This article belongs to the Special Issue Natural Products in Asia)
Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (39). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities. Dendrogibsol (2) and lusianthridin (7) showed strong α-glucosidase inhibitory activity when compared with acarbose. An enzyme kinetic study revealed that dendrogibsol (2) is a noncompetitive inhibitor of α-glucosidase. View Full-Text
Keywords: Dendrobium gibsonii; Orchidaceae; fluorene derivative; dihydrophenanthrenes; α-glucosidase inhibitory activity Dendrobium gibsonii; Orchidaceae; fluorene derivative; dihydrophenanthrenes; α-glucosidase inhibitory activity
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MDPI and ACS Style

Thant, M.T.; Chatsumpun, N.; Mekboonsonglarp, W.; Sritularak, B.; Likhitwitayawuid, K. New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity. Molecules 2020, 25, 4931. https://doi.org/10.3390/molecules25214931

AMA Style

Thant MT, Chatsumpun N, Mekboonsonglarp W, Sritularak B, Likhitwitayawuid K. New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity. Molecules. 2020; 25(21):4931. https://doi.org/10.3390/molecules25214931

Chicago/Turabian Style

Thant, May Thazin, Nutputsorn Chatsumpun, Wanwimon Mekboonsonglarp, Boonchoo Sritularak, and Kittisak Likhitwitayawuid. 2020. "New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity" Molecules 25, no. 21: 4931. https://doi.org/10.3390/molecules25214931

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